前列腺尿道夹角对α受体阻滞剂治疗良性前列腺增生患者夜尿效果的影响

林婷婷; 薛学义; 瞿根义; 许宁; 李晓东; 张磊; 陈韶展; 魏勇; 郑清水; 蔡海

摘要

Objective To evaluate the impact of the prostatic urethral angle (PUA) on nocturia symptom of benign prostatic hyperplasia (BPH) patients treated withα-receptor blockers.Methods Clinical data of 150 BPH patients with nocturia, who were treated withα-Receptor blockers, were retrospectively analyzed. Patient's age, body mass index(BMI), the before and after treatment of international prostate symptom score (IPSS), total prostate volume (TPV), transition zone volume (TZV), maximum urinary flow rate (Qmax), prostatic urethral angle(PUA),quality of life (QoL), intravesical prostatic protrusion (IPP), urethral length(UL) and other clinical indicators were collected. Logistic regression was used to evaluate factors for the improvement of nocturia symptom afterα-Receptor blockers.Results Of 150 patients, 39 (26.00%) had an improvement of nocturia symptom. The incidence of nocturia improvement in the PUA<35°group and the PUA≥35° group was 53.1% and 12.9%, respectively. After treatment, Qmax of patients increased whereas IPPS, IPSSv, IPSSs and QoL decreased, there were significant difference in the Qmax, IPPS and QoL (P<0.05). Multivariate analysis showed that the prostatic urethral angle and age could be used as predictors for improving the symptoms of nocturia after treatment ofα-Receptor blockers (P=0.041,OR=1.075,95%CI: 1.001~1.152versusP<0.001,OR=1.100, 95%CI: 1.043~1.159 ,respectively).Conclusion This study suggests that PUA can predict the results ofα-Receptor blockers treatment for nocturia suggestive of benign prostatic hyperplasia. The efficacy ofα-Receptor blockers is better for patients with PUA<35° to improve symptoms of nocturia.%目的：探讨良性前列腺增生患者前列腺尿道角（prostatic urethral angle, PUA）角度对α受体阻滞剂治疗前列腺增生症夜尿症状效果的影响。方法回顾性分析150例因夜尿增多服用α受体阻滞剂单药治疗的前列腺增生（BPH）患者，用B超经直肠测量BPH患者的PUA，收集患者年龄、体质量指数（BMI）、治疗前后国际列腺症状评分（IPSS）、前列腺体积（TPV）、移行区体积（TZV）、最大尿流率（Qmax）、前列腺尿道角（PUA）、生活质量评分（QoL）、膀胱前列腺突出（IPP）、尿道长度（UL）变化等临床指标。采用Logistic回归分析使用α受体阻滞剂后夜尿症状改善的影响因素。结果150例患者中39例（26.0%）夜尿症状改善。其中夜尿改善发生率分别为53.1%（PUA＜35°组）和12.9%（ PUA≥35°组）。使用α受体阻滞剂后，Qmax较前增加，IPSS、IPSS排尿症状评分（IPSSv）、IPSS存储症状评分（IPSSs）、QoL较前减少，差异具有统计学意义（P＜0.05）。多因素分析显示PUA角度（P=0.041，OR=1.075，95%CI：1.001-1.152）和年龄（ P＜0.001，OR=1.100，95%CI：1.043-1.159）可作为使用α受体阻滞剂改善夜尿症状的预测因素。结论结果显示PUA可以预测α受体阻滞剂治疗良性前列腺增生夜尿症状治疗效果。IPP＜35°患者，α受体阻滞疗效较好，可改善前列腺增生患者夜尿症状。

前列腺尿道夹角对α受体阻滞剂治疗良性前列腺增生患者夜尿效果的影响

摘要

著录项

相似文献

相关主题

期刊订阅