p38 MAPK signaling pathway is an important regulatory pathway during differentiation of myoblasts. P38 MAPK protein is activated by the upstream activators, such as MAKK3 and MAKK6, and its downstream factors, such as MyoD, Myf5, myogenin, MRF4 and other muscle regulatory factors, are activated during the differentiation of myoblasts. The activation of p38 MAPK signaling pathway can further increase protein content, fiber length and cross-sectional diameter of skeletal muscle fibers, which greatly improve the skeletal muscle fiber quality without changing the fiber amount. The mechanism of p38 MAPK signaling pathway in regulating skeletal muscle growth and development is reviewed in the article.%p38丝裂原活化蛋白激酶(MAPK)信号途径是成肌细胞分化过程中重要的调节途径.p38 MAPK蛋白在成肌细胞分化过程中受上游丝裂原活化蛋白激酶激酶3(MKK3)、丝裂原活化蛋白激酶激酶6( MKK6)的激活而活化其下游成肌分化蛋白(MyoD)、肌生成素5(Myf5)、肌形成蛋白(myogenin)、肌肉调节因子4(MRF4)等肌肉调节因子.p38 MAPK信号途径的活化可以进一步增加骨骼肌纤维细胞蛋白含量,增加肌纤维长度和横截面直径,使骨骼肌纤维在数量不变的前提下质量大幅度提高,本文就p38 MAPK信号途径调节骨骼肌生长发育的机理进行综述.
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