Ionic exchanger AD⁃1 was used to study the adsorption of Neu5Ac from its aqueous solution. The maximal adsorption capacity of Neu5Ac onto the resin was 0�39 g/g, temperature independent, through a batch equilibrium system. The Langmuir isotherm was used to describe the thermodynamics. The macropore diffusion and the macropore⁃micropore diffusion in series accounted for the diffusion process of Neu5Ac- ions into the resin pores,the macropore diffusivity was 1�453×10-8 m2/min while the micropore diffusivity was 9�153 × 10-15 m2/min. The influence of the particle size on the ion⁃exchange process was also studied through the macropore⁃micropore diffusion model,which indicated that kinetics of the process could be improved by using smaller adsorbent particles. Good fitting was achifeved with the model,which verifies the accuracy of the model.%主要研究了N 乙酰神经氨酸（ Neu5Ac）在AD 1离子交换树脂上的吸附行为。通过静态摇瓶的方法，利用Langmuir模型对热力学平衡数据进行拟合，测得树脂的最大Neu5Ac吸附量为0�39 g／g，且不受温度影响。依次用大孔扩散模型、大孔微孔扩散模型对不同Neu5Ac初始质量浓度的动力学数据进行拟合，结果表明，在较低浓度和较高浓度下，Neu5Ac在AD 1树脂上的离子交换过程的限速步骤依次为大孔扩散和大孔微孔扩散，其中大孔扩散系数Dp为1�453×10－8 m2／min，微孔扩散系数Dc为9�153×10－15 m2／min。最后利用大孔微孔扩散模型研究了树脂颗粒度大小对Neu5Ac在AD 1树脂上的离子交换动力学的影响，发现选取较小颗粒度的树脂有利于提高离子交换速率，且模型与实验数据吻合较好，从而验证了模型的准确性。 AD 1树脂对Neu5Ac有较大的吸附容量和较快的吸附速率。
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