Purpose To summarize the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of mammary analogue secretory carcinoma of salivary glands(MASC). Methods Four cases of MASC were included. The clinical, histological, and immunohistochemical features and follow-up data were evaluated. Results The patients aged between 20 to 72 years. Two cases were male and two were female. The average age was 52.2 years. All cases showed infiltrative growth and diverse cytology and histology, including lobular, cystic papillary, solid, cribriform or glandular structures, and microcystic honeycombed pattern composed of small cysts merged into larger cysts resembling thyroid follicles. There were no necrosis, nerve or vascular invasion in 4 cases. S-100 protein, Mammaglobin or SOX10 were strongly positive in all MASC cases.3 cases were insignificant positivity for GATA-3. Both p63 and DOG-1 were negative. Conclusion MASC is a lowgrade malignant epithelial tumor of salivary glands. Combined immunohistochemical positivity of S-100 protein, Mammaglobin and SOXIO, or negative for DOG-1, are useful in the diagnosis and differential diagnosis of MASC.%目的 探讨涎腺分泌性癌(mammary analogue secretory carcinoma, MASC)的临床病理特征、免疫表型、诊断与鉴别诊断.方法 回顾性分析4例MASC的临床病理学及免疫表型特征,并进行随访.结果 4例患者中2例女性,2例男性.年龄20 ～72岁,平均2岁.4例镜下均呈浸润性生长,形成微囊、囊性-乳头状、腺管状或实性巢状、片状生长结构;部分腺管状腔内或微囊类似甲状腺滤泡;4例均未观察到坏死、神经或脉管侵犯现象.免疫表型:4例S-100蛋白、Mammaglobin、SOX10均呈弥漫强阳性;3例GATA-3弥漫强阳性;4例p63和DOG-1均阴性.结论 MASC是一种低度恶性的涎腺上皮源性肿瘤,免疫组化标记S-100蛋白、Mammaglobin、SOX10和DOG-1及联合应用对MASC的诊断及鉴别诊断有较大价值.
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