Purpose To explore the clinicopathologic features of the mucinouscarcinoma of kidney. Methods More than 2 000 cases of renal tumor were retrospectively reviewed and 3 cases of mucinouscarcinoma were found. Immunohistochemical study was carried out in the 3 cases of paraffin-embedded tissue and relevant literatures were reviewed. Results In the 3 cases of mucinouscarcinoma, serum levels of CEA and CAI99 typically increased before operation and returned to normal after that. One case of mucinouscarcinoma had neuroendocrine differentiation together with a horseshoe kidney. The histochemical staining of AB/PAS and AB/HID showed incomplete intestinal metaplasia of intestinal epithelium. Conclusions Mucinous tumor is a very rare type of renal tumor. It may origin from intestinal metaplasia of urothelium. Detection of serum CEA and CAI99 may help to diagnose the tumor and to moniter its early recurrence.%目的 观察3例肾脏原发性黏液性肿瘤的临床病理特征.方法 回顾性分析2 000余例肾脏肿瘤,其中3例肾脏原发性黏液性肿瘤,分析其临床病理特征并复习相关文献.结果 3例均呈囊性病变,囊壁均可见衬覆肠黏膜样腺上皮,细胞有明显异型性,肿瘤细胞内均可见黏液产生;3例腺上皮均形成乳头状结构.3例囊内均充满黏液,2例为多房囊样,2例囊内见实性肿瘤团块伴囊壁间质浸润性生长.临床有结石或其他导致尿路梗阻病史,常伴发血清CEA和CA199水平升高,术后降至正常.其中1例为马蹄肾同时发生黏液腺癌伴神经内分泌分化.AB/PAS、HID染色提示为不完全性小肠型肠上皮化生.结论 肾脏黏液性肿瘤是一种罕见尿路上皮来源肿瘤,其发病与尿路梗阻所致尿路上皮肠上皮化生有关,术后检测CEA和CA199水平有利于了解肿瘤转移与复发.
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