Purpose To investigate the clinical features and histopathology of Castleman' s disease ( CD ) and analyze their prognosis,so as to deepen the recognization of the disease and provide basis for diagnosis. Methods Fifteen CD patients ' clinical and pathological information, including the cases of consultation during the same period, were retrospectively analyzed in the first affiliated hospital of Xinjiang Medical University from December 2002 to August 2010. Some cases were producted the HE sections again and added the immunohistochemistry of related factors. Results There were eight males and seven females whose average age were forty-six. The multicentric Castleman ' s disease was more common( 53. 3％ ). Clinical manifestations of the multicentric CD were widespread lymphadenopathy and accompanied with systemic symptom such as fever, fatigue. The histologica type was divided into hyaline vascular type and plasma cell type. The chemotherapy effect of CHOP or COP was good. The unicentric CD ( 46. 70％ ) just presented with local lymphadenopathy and was classified as the hyaline vascular type. The patients were cured by surgical resection of lymph node. Conclusion The clinical manifestations of CD are atypical and the main diagnosis are based on histopathology and immunohistochemistry, the prognosis of the unicentric CD is better than multicentric CD.%目的 探讨Castleman病(Castleman's disease,CD)的临床特征和组织病理学表现,分析其预后,为诊断提供参考.方法 回顾分析新疆医科大学第一附属医院2002年12月～2010年8月及同期会诊病例中明确诊断的15例CD患者的临床和病理资料,对部分病例重新制作HE切片及相关因子的免疫组化补充,并进行随访.结果 15例CD患者中男性8例、女性7例,平均年龄46岁.临床以多中心型多见(占53.3%),表现为全身多处淋巴结肿大,同时伴随有发热、乏力等全身症状或多系统受累表现,病理形态学可表现为透明血管型或浆细胞型,给予CHOP或COP方案化疗,效果良好;局灶型(占46.7%)仅表现为局部淋巴结肿大,病理形态学多表现为透明血管型,手术切除肿大淋巴结后治愈.结论 CD的临床表现不典型,组织病理学形态及免疫组化为该病最主要的诊断依据,局灶型较多中心型患者预后好.
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