Purpose To investigate the relationship between MTDH expression and clinical pathology and VEGF expression of non-small cell lung cancer ( NSCLC ). Methods MTDH and VEGF expression in the carcinomas and adjacent normal tissues was detected by the immunohistoehemical method in 328 cases of NSCLC treated with surgery. The relationship between VEGF, clinicopathologial data and MTDH were analyzed. Results MTDH expression of the cancer tissues was significantly higher than that in the adjacent normal tissues and its over and ectopic expression was positively correlated with the expression of VEGF, histological grade, TNM stage and lymph node metastasis in NSCLC ( P < 0. 05 ). Conclusion Overexpression or ectopic expression of MTDH in NSCLC suggests poor prognosis, which may be acted as an important regulatory factor of angiogenesis involving in cancer growth, metastasis and proliferation in coordination with VEGF. Joint detection of them can be used as a NSCLC potential metastatic and prognostic factor.%目的 探讨MTDH基因表达及血管内皮生长因子(VEGF)表达与非小细胞肺癌(non-small cell lung cancer,NSCLC)临床病理的关系及意义.方法 用免疫组化EnVision两步法检测328例NSCLC手术治疗患者癌组织和癌旁组织中MTDH及VEGF蛋白表达,分析其在NSCLC临床病理中的关系、应用价值及两者在癌组织血管形成中的协同作用.结果 328例NSCLC中MTDH表达明显高于癌旁正常肺组织,MTDH过表达和异位表达与NSCLC的VEGF蛋白表达、组织学分级、TNM分期及淋巴结转移呈密切正相关性(P值均＜0.05).结论 NSCLC中MTDH过表达或异位表达提示患者预后差,同时作为血管发生的重要调控因子与VEGF协同参与NSCLC的生长、转移和扩散,联合检测将作为NSCLC转移潜能和预后的指标.
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