Objective To observe the relationship between helicobacter pylori ( Hp) infection and nocturnal acid breakthrough ( NAB) in patients with gastroesophageal reflux disease ( GERD). Methods 85 cases of GERD patients detected by rapid urase test with gastric antrum biopsy and 14C-UBT were diagnosed Hp positive. All of the cases were divided into two groups randomty including experimental group(43 eases) and control group (42 cases). Experimental group was given Hp eradication therapy,control group was treated with sodium pantopiazolc moiiotherapv,7 days as a course,24 h monitor of gastric pH and reflux disease questionnaire( RDQ) scores were compared before,and after treatment. Results The rate of NAB in experimental group was 62. 79% ,and the control group was 38. 10% ,the difference was significant ( P <0. 05) . There was significant difference in RDQ scores between the two groups after treatment ( P < 0. 05 ). Conclusion Hp infection could reduce the occurrence of NAB and protect GERD probably.%目的 探讨幽门螺杆菌(Hp)感染与胃食管反流病(GERD)患者夜间酸突破(NAB)的相关性.方法 85例经活检胃窦组织快速尿素酶法及14C呼气试验法进行Hp检测确诊为Hp阳性的胃食管反流病患者随机分为两组,试验组(43例)予根除Hp治疗,对照组(42例)单用泮托拉唑钠治疗,疗程共7 d,两组治疗前后行24 h胃pH值监测及反流诊断问卷评分(RDQ),并进行比较.结果 试验组夜间酸突破的发生率为62.79％,对照组为38.10％,两组比较差异有统计学意义(P＜0.05)；两组治疗后RDQ评分差异有统计学意义(P＜0.05) 结论 Hp感染可减少NAB的发生,可能对GERD的发生有保护作用.
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