Objective To explore the Ye Tianshi's regularities and characteristics of medications in the treatment of menopathy.Method We sorted out the ancient medical cases about menopathy from Ye's books-A Guide to Clinical Practice and Unpritend Ye's Medical Records.EXCLE 2010,SPSS Clementine (ver.11.1),SPSS (ver.22.0),and Liquorice software were adopted for frequency analysis,association rules analysis,cluster analysis and the analysis of complex network on the extracting herbs in these cases.Results (1) Medication frequency and of the nature and flavor analysis of herbs:high-frequency herbs (with more than 0.20 frequency) include:radix paeoniae alba (0.37),angelica sinensis (0.36),poria cocos (0.35),ginseng (0.25),donkey-hide gelatin (0.20),jujube (0.20),liquorice (0.20),cassia twig(0.20).The sweet taste herbs and warm herbs were used most whether in all the herbs or the highfrequency herbs.(2) Association rules analysis showed that the four most common herb-groups were:cassia twig,radix paeoniae alba,jujube;cassia twig,jujube,licorice;radix paeoniae alba,jujube,licorice;radix paeoniae alba,donkeyhide gelatin,radix rehmanniae.(3) Clustering analysis obtained three herb-groups were mainly compatibilities of yangactivating drugs and yin-nourishing drugs:cassia twig,jujube,liquorice,rhizoma zingiberis recens,radix paeoniae alba,radix glycyrrhizae preparata;fennel,rhizoma cyperi,angelica,poria cocos;radix rehmanniae,donkey-hide gelatin,calcined oyster shell,ginseng,poria peel cortex poriae cocos.(4) Complex network analysis obtained the core prescription herbs were angelica,radix paeoniae alba,poria cocos,ginseng,rhizoma cyperi,liquorice,radix rehmanniae,donkey-hide gelatin,cassia twig,jujube.Conclusion Ye Tianshi used sweet taste herbs and warm herbs most frequently when treating menopathy.Ye recombined the classical formulas flexibly into common herb-groups for harmonizing ying and wei,enriching yin and activating yang,removing stasis and stopping blood.He also payed attention to the balance of nourishing and circulating of qi and blood.%目的 探索叶天士治疗月经病的用药规律及特点.方法 整理《临证指南医案》《未刻本叶氏医案》中关于月经病的医案.采用EXCEL 2010、SPSS Clementine 11.1、SPSS 22.0、Liquorice软件进行药物频数分析、关联规则分析、聚类分析和复杂网络分析.结果 (1)药物频数、性味分析:出现频率在0.20以上的高频药物有:白芍(0.37)、当归(0.36)、茯苓(0.35)、人参(0.25)、阿胶(0.20)、大枣(0.20)、甘草(0.20)、桂枝(0.20),在所有药物和高频药物中,甘味药和温性药均出现最多.(2)关联规则分析得出最常见的4个药组为:桂枝、白芍、大枣;桂枝、大枣、甘草;白芍、大枣、甘草;白芍、阿胶、生地.(3)聚类分析得出3组药物,分别为:桂枝、大枣、甘草、生姜、白芍、炙甘草;小茴香、香附、当归、茯苓;生地、阿胶、煅牡蛎、人参、茯神,主要为通阳药和养阴药的配伍.(4)复杂网络分析得出核心处方药物为:当归、白芍、茯苓、人参、香附、甘草、生地、阿胶、桂枝、大枣.结论 叶天士治疗月经病多用甘味药与温性药,通过灵活化裁经方,组合成调和营卫、益阴、通阳、化瘀止血的常用药对,且注重兼顾充养胞宫气血和活血通经两方面的治疗.
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