Objective To study the effect of menopausal hormone therapy (MHT)on the vaginal microecology for postmenopausal women.Methods A total of 322 postmenopausal women in gynecology outpatient department were selected and divided into post-menopausal less than 5 years group,post-menopausal from 5 to10 years and post-menopa-usal more than 5 years group.According to the MHT treatment,and the patients were also divided into MHT group (MHT +,n =104)and never MHT use group (MHT -,n =218).The changes of vaginal micro ecological environment were compared.Results Bacterial vaginosis(BV)was the most common disease in postmenopausal women.The posi-tive rate of BV in different menopause groups were 21.1% in less than5 years group,19.3% in from 5 to 11 years group and 16.0% in more than 11years group,respectively.The positive rate of abnormalbacteria colonies/function in MHT +group was significantly lower than those in MHT - group (P <0.05).Normal bacteria colonies in MHT + group was sig-nificantly higher than those in MHT -(P <0.01).Conclusions BV is one of the most common genital tract infections in postmenopausal women.MHT is helpful to improve the vaginal micro ecology.%目的：探讨绝经后激素补充治疗（MHT）对绝经女性阴道微生态的影响。方法选择妇科门诊就诊的绝经女性322例，按绝经时间分为≤5年组、＞5年且＜11年组和≥11年组；按照 MHT 使用与否分为使用MHT 组（n ＝104）与未使用 MHT 组（n ＝218）；取阴道分泌物进行微生态检测，比较各组阴道微生态的数据。结果细菌性阴道病在不同绝经时间组中的发病率最高，在≤5年组为21．1％、＞5年且＜11年组为19．3％、≥11年组为16．0％；使用 MHT 组菌群／功能异常的阳性率明显低于未使用 MHT 组（P ＜0．05）；使用 MHT 组菌群正常率显著高于未使用 MHT 组（P ＜0．01）。结论细菌性阴道病是绝经女性常见的阴道感染性疾病之一。MHT有助于阴道微生态的改善。
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