目的：探讨血尿酸水平和冠心病慢性心功能不全的关系。方法将296例冠心病患者分为两组：心功能正常组173例，心功能不全组123例，心功能不全组按纽约心脏病学会NYHA分级分为心功能Ⅱ级组（n＝31），心功能Ⅲ级组（n＝40），心功能Ⅳ级组（n＝52）。应用尿酸氧化酶法测定血尿酸浓度。结果①心功能正常组血尿酸浓度（330．62±89．21）μmol/L，高尿酸血症发生率21．97％；心功能不全组血尿酸浓度（415．63±100．30）μmol/L，高尿酸血症发生率50．41％（P＜0．01）。②心功能Ⅱ级亚组血尿酸浓度（362．37±101．01）μmol/L，高尿酸血症发生率25．81％；心功能Ⅲ级亚组血尿酸浓度（389．12±100．37）μmol/L，高尿酸血症发生率35．00％；心功能Ⅳ级亚组血尿酸浓度（427．21±98．33）μmol/L，高尿酸血症发生率82．69％；各组间血尿酸水平差异有统计学意义（P＜0．05）。结论冠心病慢性心功能不全患者血尿酸水平升高，血尿酸水平与心功能不全的严重程度呈正相关。%Objective To investigate the relationship between serum uric acid and chronic cardiac insuffi-ciency of patients with coronary heart diseases.Methods Patients with coronary heart diseases were divided into 2 groups:normal cardiac function group(173cases)and cardiac dysfunction group(123cases).According to the New York Heart Association(NYHA)criteria,a total of 173 cardiac dysfunction patients were divided into Group NYHAⅡ(n=31),Group NYHAⅢ(n=40),Group NYHAⅣ(n=52),The level of SUA was measured with urate oxidase method.Results (1)The mean SUA level in normal cardiac function group was(330.62 ±89.21)μmol/L,and the total incidence of hyperuricemia(HUA)was 21.97%.The mean SUA level in cardiac dysfunction group was (415.63 ±100.30)μmol/L,and the total incidence of HUA was 50.41%.(2)The mean SUA level in patients with NYHAⅡ,NYHA Ⅲ,NYHA Ⅳwas (362.37 ±101.01)μmol/L,(389.12 ±100.37)μmol/L,and (427.21 ±98.33)μmol/L respectively,and the incidences of HUA were 25.81%,35.00%,and 82.69%respectively.There was signif-icant difference in SUA among these groups(P<0.05 ).Conclusion The mean SUA level in patients with cardiac dysfunction is higher than patients with normal cardiac function.There is a positive correlation between the level of SUA and the severity of cardiac dysfunction.
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