Objective To study the effecls of high flux hemodialysis and low-flux hemodialysis two melhods on the nulrilional slalus of palienls with uremia. Methods In a self-control sludy, 40 palienls undergoing maintenance low flux hemodialysis were assigned to receive high-flux hemodialysis for 10 monlhs. Serum albumin ( Alb) ,the hemoglobin ( Hb) , paralhyroid hormone ( iPTH) , phosphale subjective global assessment( SGA) , and appelile score were measured after 10 monlhs. Results Of 40 palienls wilh maintenance hemodialysis ( MHD) , before and after HFHD treatmenl. Serum Alb was 38. 2 ±4.4 and 41. 5 ±7.2 g/L. Hb was 77. 12 ±4.63 and 101.4 ±8.67 g/L. iPTH was 654.3 ±750. 1 and 304.7 ±898.9 ng/L. blood phosphorus was 2. 34 ±0. 51 and 1. 68 ± 0. 45 mmol/L. respectively. SGA and appelile score superiorly increase before and afler trealmenl. All data represenl a statistically significant difference ( P<0. 05) . Conclusion MHFD can increase serum albumin levels, hemoglobin levels and reduce paralhyroid hormone ( iPTH) and phosphale levels, improve nutrition stale in uremic palienls.%目的 研究高通量血液透析(HFHD)和低通量血液透析(LFHD)两种方法对尿毒症患者营养状态的影响.方法 采用自身对照研究方法对40例维持性低通量血液透析(LFHD)患者,改用HFHD 10个月,分别测定患者血清白蛋白(Alb)、血红蛋白(Hb)、全段甲状旁腺激素(iPTH)及电解质水平,进行主观综合性营养评估(SGA)及食欲评分.结果 40例维持性血液透析(MHD)患者HFHD治疗前后,Alb分别为(38.2±4.4)g/L、(41.5±7.2)g/L,Hb(77.12±4.63)g/L、(101.4±8.67)g/L,iPTH为(654.3±750.1)ng/L、(304.7±898.9)ng/L,血磷(2.34±0.51)mmol/L、(1.68±0.45)mmol/L,SGA评估及食欲评分治疗前较治疗后显著升高,两两比较差异有统计学意义(P<0.05 ).结论 HFHD能提高患者的血清白蛋白水平,纠正贫血,降低iPTH及血磷水平,较好地改善患者的营养状态.
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