Objective To evaluale the effecl of intensive insulin trealmenl on oxidalive slress level of pa-lienls with early stage diabetic cardiomyopalhy ( DCM) . Methods Sixty palienls with early stage DCM who received conlinue subculaneous insulin injeclion belween February 2009 and May 2012 were recruiled. Serum superoxide dis-mulase ( SOD) , Glulalhione peroxidase ( GSH-PX) and malondialdehyde (MDA) were measured after insulin pump therapy. Results After the trealmenl, There were significanl improvements in serum SOD and GSH-PX 「 ( 118.40 ± 25.41) vs ( 171. 16 ±27.76) U/ml and ( 120. 53 ±46. 26) vs( 175. 58 ±52. 37) enzyme activity unit」 . respectively ( P <0. 01 ) . On the other hand, serum MDA significantly decreased r ( 49. 53 ± 14. 42) vs ( 22. 65 ± 12. 54) nmol/ml」 ( P <0. 01) . Cardiac diaslolic funclion was significanlly improved 「 ( 0. 74 ± 0. 35) vs (1. 09 ± 0. 23) 」 ( P <0. 01) . Conclusion Ailer intensive insulin treatment, oxidative stress level significantly decreased and cardiac diastolic function significantly improved in patients with early stage DCM.%目的 评价早期糖尿病性心肌病(DCM)患者胰岛素泵强化治疗前后氧化应激水平的变化.方法 对确诊的60例早期DCM患者采用胰岛素泵强化治疗,治疗达标前后进行超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)水平测定,进行比较.结果 胰岛素泵强化治疗后,患者血浆中的SOD和GSH-PX水平明显上升(P<0.01)、MDA明显下降(P<0.01).空腹血糖、餐后2 h血糖、胰岛素抵抗指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、游离脂肪酸水平明显降低(P＜0.05),胰岛素分泌功能指数明显上升 [(10.70±5.98)vs(74.30±10.18)mmol/L,P＜0.05].心脏舒张功能(E/A)明显改善.结论 早期DCM患者使用胰岛素泵强化治疗可明显降低氧化应激水平,改善心脏舒张功能.
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