目的 探讨绝经后妇女口服阿仑膦酸钠引发食管炎对患者耐受性的影响.方法 采用临床配对平行对照研究.计划入组病例60例,评估后,入选患者均经胃镜检查,经配对分入试验组或对照组.试验治疗疗程为12个月,在治疗前、6个月末和12个月末对阿仑膦酸钠引发食管炎的安全性进行评估.结果 治疗后骨密度明显上升,阿仑膦酸钠组与碳酸钙组比较差异有统计学意义(P<0.01).食管炎的发生率两组差异无统计学意义(碳酸钙组:14.17%、阿仑膦酸钠组:15.83%).结论 阿仑膦酸钠在增加骨密度、减少骨折的同时,并无增加食管炎甚至食管溃疡的风险.%Objective To invesligale incidence of esophagilis and other side effecl of alendronale in the trealmenl on poslmenopausal osleoporosis. Methods The clinical paired parallel controlled study included 60 cases which were trealmenl divided into group and conlrol group after diagnosed by gaslroscopy, there was significant difference in age, body weight, bone mineral densily and the endoscopic manifestations in two groups. The study duralion was 12 monlhs. We assessed the esophagilis induced by alendronale at three poinl( prion to trealmenl, 6 monlhs and 12 monlhs) . Results After alendronale trealmenl, the bone mineral densily increased significantly ( P <0. 01) . The incidence of was nol significantly different esophagilis in two groups ( calcium carbonate group: 14. 17%, alendronale group: 15. 83% ) . Conclusion Alendronale increase bone mineral densily withoul significant adverse reactions.
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