目的：通过光斑贴试验分析氯丙嗪和磺胺引起光变应性接触性皮炎（photo‐allergic contact dermatitis ，PACD ）的情况。方法：选择2006年1月—2012年12月在复旦大学附属华山医院接受光斑贴试验的光皮肤病患者。根据国际接触性皮炎研究组（ICDRG ）的标准判读光斑贴试验结果。比较两种变应原PACD阳性率及每种变应原的PACD阳性率在不同性别、不同年龄段光皮肤病患者中的差异。结果：共4836例入组，其中接受氯丙嗪光斑贴试验者3993例，PACD阳性率44．3％；接受磺胺光斑贴试验者4836例，PACD阳性率6．9％；两种变应差异（ P＜0．0001）。接受氯丙嗪光斑贴试验的3993例中，男性PACD阳性率43．6％，女性阳性率44．7％，差异无统计学意义（ P＝0．51）；接受磺胺光斑贴试验的4836例中，男性 PACD阳性率9．3％，女性阳性率5．4％，差异有统计学意义（ P＜0．0001）。氯丙嗪PACD阳性率随年龄增加而升高，不同年龄段间差异有统计学意义（P＜0．0001）；磺胺PACD阳性率在不同年龄段间差异无统计学意义（P＝0．37）。结论：氯丙嗪 PACD阳性率明显高于磺胺。氯丙嗪PACD多见于中老年人。男性光皮肤病患者中磺胺PACD阳性率高于女性。%Objective:To investigate the incidence of photo‐allergic contact dermatitis (PACD)induced by chlorpromazine and sulfanilamide with photo‐patch testing (PPT ) .Methods :Patients who underwent PPT for suspected photo dermatoses in Huashan Hospital ,Fudan University from January 2006 to December 2012 were selected .PPT results were evaluated with the criteria of International Contact Dermatitis Research Group (ICDRG) .Photoallergic positive rate was compared between two allergen groups .And the photoallergic positive rate of each allergen was compared among different genders and ages .Results:A total of 4836 patients were enrolled .PACD positive rate was 44 .3% in 3993 subjects tested with chlorpromazine and 6 .9% in 4836 subjects tested with sulfanilamide .There was a significant difference between the two groups (P<0 .0001) .In the 3993 subjects tested with chlorpromazine ,the male PACD positive rate was 43 .6% ,while the female positive rate was 44 .7% ,and there was no statistical significance(P=0 .51) .In the 4836 subjects tested with sulfanilamide ,the male PACD positive rate was 9 .3% while the female positive rate was 5 .4% ,and there was a significant difference(P<0 .0001) .The PACD positive rate increased with age in subjects tested with chlorpromazine and there was significant difference among different ages ( P< 0 . 0001) .The PACD positive rate in subjects tested with sulfanilamide showed no statistical significance among different ages (P=0 .37) .Conclusions :Chlorpromazine presents higher PACD positive rate than sulfanilamide .The PACD of chlorpromazine mainly happens in middle‐aged and elderly people .The PACD positive rate of sulfanilamide in males is higher than that in females .
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