Objective:To investigate the classification and the maternal-fetal vertical transmission of human papillomavirus (HPV) in gestational period .Methods :A total of 500 cervical specimens of pregnant women and nasopharyngeal and genital se-cretion specimens from the newborns of HPV-postive pregnant women were detected by HPV-DNA classification assay in De-partment of Gynaecology and Obstetrics ,Qingpu Branch of Zhongshan Hospital ,Fudan University from January 2011 to De-cember 2012 .The infective rate and infective types were analyzed ,respectively .Results:HPV-DNA was positive in the cervi-cal vaginal exfoliated cells of 102 cases ,and the infection rate was 20 .4% .The most common types of HPV infection were HPV16 (4 .2% ) ,HPV52 (2 .2% ) ,HPV33 (1 .8% ) ,HPV58 (1 .8% ) ,HPV18 (1 .6% ) and HPV39 (1 .2% ) .In HPV-posi-tive pregnant women ,single-type infection was found in 88 cases (86 .27% ) ,and multiple-type infection was found in 14 cases (13 .73% ) including 11 cases of double infection and 3 cases of triple infection .Maternal-fetal HPV vertical transmission were found in 7 cases (6 .86% ) .It was found that 25 to 30 years old pregnant women had higher rate of HPV infection ,and there was no significant difference in the rate of HPV infection among women with different gestational age .Conclusions :HPV16 is the main infective type in gestational period and can be infected through maternal-fetal vertical transmission .Early screening of pregnancy women can reduce the incidence of cervical cancer and neonatal infection rate .%目的：探讨人乳头状瘤病毒（human papillomavirus ，HPV ）的感染分型及母婴垂直传播情况。方法：对2011年1月-2012年12月在复旦大学附属中山医院青浦分院产科门诊就诊的500例孕妇的宫颈脱落细胞进行HPV-DNA分型检测，并对HPV阳性孕妇分娩的新生儿的口咽部和生殖器黏膜细胞进行 HPV-DNA分型检测，分析 HPV亚型感染状况。结果：500例孕妇中HPV 阳性者102例，感染率20．40％；感染 HPV 最常见的亚型为 HPV16（4．2％）、HPV52（2．20％）、HPV33（1．80％）、HPV58（1．80％）、HPV18（1．60％）、HPV39（1．20％）。HPV阳性孕妇中，单型别感染88例（86．27％）；多重型别感染14例（13．73％），其中二重感染11例，三重感染3例。母婴 HPV垂直传播7例（6．86％）。25～30岁年龄段孕妇 HPV感染率较高，不同孕期孕妇HPV感染率差异无统计学意义（P＞0．05）。结论：孕期HPV感染以HPV16型为主，并可母婴垂直传播；妊娠期妇女早期筛查对降低宫颈癌发病率和新生儿感染率非常必要。
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