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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Maternal Swimming Pool Exposure during Pregnancy in Relation to Birth Outcomes and Cord Blood DNA Methylation among Private Well Users
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Maternal Swimming Pool Exposure during Pregnancy in Relation to Birth Outcomes and Cord Blood DNA Methylation among Private Well Users

机译：孕期孕产妇泳池暴露与私家井使用者的出生结局和脐带血DNA甲基化有关

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Background: Swimming in pools during pregnancy may expose the fetus to water disinfection by-products (DBP). As yet, our understanding of the impacts on DBPs on the fetus is uncertain. Individuals with public water systems are typically exposed to DBPs through drinking and bathing, whereas those on private systems (such as wells), swimming in pools may be the primary exposure route. Objective: To investigate the effects of maternal swimming on birth outcomes and cord blood epigenetic changes in the New Hampshire Birth Cohort Study, a cohort of pregnancy women with households on private wells. Methods: Information about swimming in pools during pregnancy was obtained from 1,046 women via questionnaires. Swimming pool use and duration were modeled using linear regression with newborn weight, length, and head circumference (z-scores) and genome wide cord blood DNA methylation as the outcomes and with adjustment for potential confounders. Results: 16.5% of women reported swimming in a pool during pregnancy. Ever (vs. never) swimming was associated with larger head circumference (a z-score increase of 0.97 for first trimester and 0.73 for second or third trimester). Among swimmers, duration was inversely related to head circumference (-0.01 z-score per 10% increase in duration, p=0.02). No clear associations were observed with birth weight or length. In a subset of the cohort with genome wide DNA methylation measurements, 18 CpG sites, mainly related to neurodevelopment, were associated with maternal swimming pool exposure (Q<0.1). Conclusion: Our findings suggest swimming pool exposure may impact the developing fetus although longer-term studies are needed.
机译：背景：怀孕期间在游泳池游泳可能会使胎儿暴露于水消毒副产物（DBP）中。到目前为止，我们对DBPs对胎儿的影响的了解尚不确定。具有公共供水系统的个人通常会通过饮水和洗浴而接触到DBP，而在私人系统（例如水井）上的人们，在泳池中游泳可能是主要的接触途径。目的：在新罕布什尔州出生队列研究中，研究孕妇游泳对出生结局和脐带血表观遗传学变化的影响。方法：通过问卷调查从1,046名妇女那里获得了有关怀孕期间在泳池游泳的信息。使用线性回归模型模拟游泳池的使用时间和持续时间，以新生儿体重，身长和头围（z得分）和全基因组脐带血DNA甲基化为结果，并对潜在的混杂因素进行调整。结果：16.5％的妇女报告说在怀孕期间在游泳池游泳。曾经游泳（相对于从来没有）与较大的头围相关（头三个月的z分数增加0.97，而中期或中期的z分数增加0.73）。在游泳者中，持续时间与头围成反比（持续时间每增加10％，-0.01 Z评分，p = 0.02）。没有观察到与出生体重或身长的明确关联。在具有全基因组DNA甲基化测量的队列子集中，主要与神经发育有关的18个CpG位点与孕妇游泳池暴露相关（Q <0.1）。结论：我们的研究结果表明，尽管需要长期研究，但游泳池暴露可能会影响发育中的胎儿。

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