情绪障碍可以影响帕金森病患者的生活质量及疾病预后.神经心理学测验和神经影像学研究发现,帕金森病患者情绪障碍可能与中脑-边缘系统、中脑-皮质多巴胺能通路损害有关,但具体的病理学机制尚待进一步研究.本文拟就帕金森病患者情绪障碍的临床表现、可能的病理生理学机制、诊断及治疗进行探讨.%Emotional impairment is the common complication of Parkinson's disease (PD).Depression,anxiety and apathy affect the quality of life and the prognosis of PD patients.Neuropsychological and neuroimaging studies of emotional impairment in PD patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways,but the specific mechanism needs further study.In this review we discuss the clinical manifestation,possible pathological mechanism,diagnosis and treatment in PD patients.
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