Objective To explore the relationship between leptin and the pulmonary function in acute exacerabation of chronic obstructive pulmonary disease ( AECOPD ) .Methods Thirty -five AECOPD patients ( AECOPD group ) , 38 COPD patients in statinary phase ( Statinary group ) and 30 healthy aged people control group were selected in this study .The serum leptin, tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) were detected.Pulmonary function test was taken.The correlation between the serum leptin level and TNF -α, CRP, lung function index were analyzed . Results ①The serum leptin , CRP and TNF-αin AECOPD group were higher significantly than those in Statinary group and Control group .The pulmonary function index -FEVl, MVV and DLCO were lower significantly than those in Statinary group and Control group .②The serum leptin level in patients with COPD had positive correlation with CRP , TNF-α, and had negative correlation with pulmonary function index-FEVl, MVV and DLCO.Conclusion Leptin is a predictor of COPD, and may be useful for assessing risk of impaired lung function .%目的：探讨血清瘦素（ leptin ）与慢性阻塞性肺疾病（ chronic obstructive pulmonary disease， COPD）急性加重期患者肺功能的关系。方法选择COPD急性加重期患者35例、COPD稳定期患者38例及健康志愿者30例，抽取空腹血。用放免法测定血清瘦素、用酶联免疫吸附法（ELISA）测定肿瘤坏死因子-α（TNF-α）及用全自动生化仪检测C-反应蛋白（CRP）；检测肺功能，记录1 s用力呼气量（ FEVl ）、最大通气量（ MVV）、肺一氧化碳弥散量（ DLCO ）等指标、分析COPD急性加重期患者血清瘦素水平与TNF-α、CRP、肺功能等的相关性。结果①COPD急性加重期患者血清瘦素、TNF-α、CRP均明显高于COPD稳定期组和对照组，而FEVl、MVV、DLCO则明显低于后者；②COPD急性加重期患者血清瘦素与TNF-α、CRP呈正相关，与FEVl、MVV、DLCO呈负相关。结论血清瘦素可判断COPD急性加重期预后，可以评估肺功能损害风险。
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