Objective To investigate the relationship between serum levels of PARK7,LPA and D-dimer(D-D)in patients with stroke and the degree of carotid atherosclerosis and nerve defect.Methods One hundred and twenty cases of patients with acute stroke from Jingmen second people''s hospital were divided into non-plaque group(n=20),plaque stable group(n=48)and unstable plaque group(n=52)accorded to carotid intima media thickness(IMT)from October 2015 to October 2016.40 cases of healthy volunteers were selected as the control group.The levels of PARK7,LPA and D-D in the serum of each group were measured by ELISA.The neurological deficits of patients with acute stroke were assessed with NIHSS scoring scale.Results The levels of PARK7,LPA and D-D of unstable plaque group were higher than stable plaque group and non-plaque group,the levels of PARK7,LPA and D-D in stable plaque group were higher than non-Plaque group(F=127.53,F=325.37,F=242.49,P<0.01).The levels of PARK7,LPA and D-D in the moderate and severe nerve defect groups were significantly higher than mild neurologic deficits group,while the levels of PARK7,LPA and D-D in severe nerve defect group were higher than moderate group(F=166.99,F=177.44,F=228.12,P<0.05).The levels of PARK7,LPA and D-D of progressive stroke were higher than stroke patients(t=7.991,t=5.626,t=19.887,P<0.01).The levels of serum PARK7,LPA and D D in dead group were higher than survival group(t=11.162,t=4.209,t=28.825,P<0.01).The levels of PARK7,LPA and D-D were positive correlated with IMT and NIHSS by Pearson univariate analysis(RIMT=0.352、0.315、0.329;RNIHSS=0.345、0.329、0.338,P<0.01).Conclusion The levels of serum PARK7,LPA and D-D in patients with acute stroke are closely related to the stability of carotid plaque and the degree of neurological deficit.It can be used as an important index to evaluate the prognosis of stroke patients.%目的 分析脑卒中患者血清人帕金森蛋白7(PARK7)、溶血磷脂酸(LPA)和D-二聚体(D-D)水平与颈动脉粥样硬化及神经缺损程度的关系.方法 选取2015年10月-2016年10月湖北省荆门市第二人民医院神经内科脑卒中患者120例(脑卒中组),根据颈动脉内膜-中层厚度(IMT)分为无斑块组(n =20)、斑块稳定组(n =48)及斑块不稳定组(n =52),另选取健康体检者40例为健康对照组,应用ELISA法测定各组血清PARK7、LPA和D-D水平,并应用美国国立卫生研究所卒中量表(NIHSS)评分评价急性脑卒中患者神经功能缺损情况,分析PAPK7、LPA、D-D与颈动脉粥样硬化及神经缺损程度关系.结果 与健康对照组比较,脑卒中组PAPK7、LPA、D-D水平升高(P<0.05);脑卒中不稳定斑块组血清PARK7、LPA和D-D水平>稳定斑块组>无斑块组(F =127.53、325.37、242.49,P <0.01).与脑卒中轻度神经缺损组比较,中度、重度神经缺损组血清PARK7、LPA和D-D水平显著升高,而重度神经缺损组血清PARK7、LPA和D-D水平高于中度神经缺损组(F =166.99、177.44、228.12,P <0.01).与非进展性脑卒中相比,进展脑卒中患者血清PARK7、LPA和D-D水平显著升高(t =7.991、5.626、19.887,P <0.01).与存活组相比,死亡组血清PARK7、LPA和D-D水平显著升高(t =11.162、4.209、28.825,P <0.01).经Pearson单因素分析可知,PARK7、LPA和D-D与IMT、NIHSS评分呈正相关(r IMT=0.352、0.315、0.329,r NIHSS=0.345、0.329、0.338,P <0.01).结论 急性脑卒中患者血清PARK7、LPA和D-D水平与颈动脉斑块稳定性及神经功能缺损程度有密切的关系,可作为评估脑卒中患者预后重要指标.
展开▼
