目的 分析高敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)和血清胱抑素C(cystatin C,Cys C)对糖尿病肾病的临床诊断价值.方法 选取2013年6月至2016年11月本院收治的2型糖尿病伴糖尿病肾病患者72例纳入糖尿病肾病组,单纯2型糖尿病患者70例纳入单纯糖尿病组;另选取同期本院体检健康者72例纳入对照组.检测分析三组研究对象血清hs-CRP和Cys C水平.结果 糖尿病肾病组患者hs-CRP和Cys C水平均显著高于单纯糖尿病组和对照组(P<0.05);单纯糖尿病组患者hs-CRP和Cys C水平均显著高于对照组(P<0.05);正常白蛋白尿组患者血清hs-CRP和Cys C水平均显著低于大量白蛋白尿组(P<0.05).糖尿病肾病组患者血清hs-CRP和Cys C阳性率均显著高于单纯糖尿病组和对照组(P<0.05);单纯糖尿病组患者血清hs-CRP和Cys C阳性率均显著高于对照组(P<0.05).联合检测诊断糖尿病肾病的灵敏度、特异度、准确率分别为95.8%%、84.7%、90.3%,灵敏度和准确率较单一指标诊断结果均显著提高(P<0.05).结论 血清hs-CRP和Cys C是糖尿病肾病的敏感指标,联合检测对糖尿病肾病具有较高的诊断价值.%Objective To analyze the clinical value of high sensitivity C reactive protein (hs-CRP) and serum cystatin C (Cys C) in diagnostic of diabetic nephropathy. Method 72 cases of diabetes mellitus type 2 patients with diabetic nephropathy from June 2013 to November 2016 in our hospital were allocated into diabetic nephropathy group, 70 cases of diabetes mellitus type 2 patients were allocated into diabetes group, and 72 healthy person were allocated into control group during the same period. The levels of serum hs-CRP and Cys C among the three groups were detected and analyzed. Result The levels of hs-CRP and Cys C in diabetic nephropathy group were significantly higher than that of diabetes group and control group (P < 0.05);the levels of hs-CRP and Cys C in diabetes group were significantly higher than those in control group (P < 0.05); the levels of hs-CRP and Cys C in normal serum albumin urinary group were significantly lower than macroalbuminuria group (P < 0.05). The positive rates of serum hs-CRP and Cys C in diabetic nephropathy group were significantly higher than those of diabetes group and control group (P < 0.05); the positive rates of hs-CRP and Cys C in diabetic nephropathy group were significantly higher than diabetes group and control group (P < 0.05), the positive rates of hs-CRP and Cys C in diabetes group were significantly higher than control group (P < 0.05). The sensitivity, specificity and accuracy of combined detection for diagnosis of diabetic nephropathy were 95.8%, 84.7% and 90.3%, respectively. Sensitivity and accuracy were significantly higher than that of single detection (P < 0.05). Conclusion Serum hs-CRP and Cys C are sensitive diagnose indicators of diabetic nephropathy, and combined detection has a higher diagnostic value for diabetic nephropathy.
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