ObjectiveTo study the effect of different treatment opportunities on the pregnancy outcome and fetal prognosis of pregnant women with syphilis.Method66 cases of pregnant women with syphilis were selected from August 2008 to August 2012 in our hospital for the study, according to the different treatment opportunities, they were divided into group A (gestational weeks<12 weeks), group B (13 weeks 29 weeks), compared three groups patients with pregnant outcomes, incidence of neonatal congenital syphilis, maternal RPR titer.ResultAfter treatment, term delivery rate and premature delivery rate of three groups were signiifcant difference (P<0.05), whereas the incidence of low birth weight infant, abortus, fetal death of three groups had no signiifcant difference (P>0.05). Group A were all normal neonate, congenital syphilis incidence of group B and group C was 2.85% and 20.00% respectively, signiifcantly higher than group A (P<0.05). Group A RPR titer<1︰8 was highest among three groups, group C was the lowest, the difference between the three groups was signiifcant (P<0.05). ConclusionEarly treatment for women with syphilis can improve pregnancy outcomes and fetal outcomes, which can effectively reduce syphilis infection rate and it is safe.%目的：探究不同治疗时机对妊娠合并梅毒患者妊娠结局及胎儿预后的影响。方法选取2008年8月至2012年8月本院收治的66例妊娠合并梅毒患者为研究对象，按照不同治疗时机将患者分为A组（孕周＜12周）、B组（孕周13～28周）、C组（孕周＞29周），比较三组患者妊娠结局、先天梅毒患儿发生率及母婴RPR滴度。结果三组患者足月分娩率、早产率比较差异具有显著性（P＜0.05），而三组低体重儿、流产、死胎的发生率比较差异均无显著性（P＞0.05）。A组中均为正常新生儿，B组和C组先天梅毒患儿发生率分别为2.85%和20.00%，显著高于A组（P＜0.05）。A组中RPR滴度＜1︰8者比例最高，C组最低，组间比较差异具有显著性（P＜0.05）。结论早期诊断及科学规范的抗梅毒治疗能够明显改善梅毒患者妊娠结局，降低新生儿早产率以及先天梅毒患儿的发生率，对新生儿预后意义重大，安全性高。
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