Liver fibrosis is the common pathology of chronic liver diseases, and can evolve into cirrhosis and related complications. It is believed that liver fibrosis is invertible. Therefore, the diagnosis of liver fibrosis is important for the prevention and prognosis of chronic liver diseases. Liver biopsy has always represented the standard of reference for assessment of liver fibrosis, but has some limitations. Recently, it is found there is fine correlation between liver fibrosis and serological indexes which is easy to carry out and expected to replace liver biopsy. This review focuses on advances in the researches of the serological diagnosis of liver fibrosis.%肝纤维化是多种慢性肝病的共同病理过程,可导致肝硬化及相关并发症的发生,而肝纤维化具有可逆性.因此,肝纤维化诊断对慢性肝病的防治及预后评估具有重要意义.肝活检一直是诊断肝纤维化的金标准,但有其局限性,近来研究发现血清学指标与肝纤维化之间有良好的相关性,且简便易行,有望替代肝活检,本文就血清学检查在肝纤维化诊断中的研究作一概述.
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