Background:Eosinophilic gastroenteritis is the most common gastrointestinal allergic disease,however,allergy also accounts for some gastrointestinal functional disorders. The correlation between allergic factor and intestinal polyp is not clarified. Aims:To investigate the correlation of allergic factor with intestinal polyp and irritable bowel syndrome(IBS). Methods:Ninety-five inpatients including 60 cases of intestinal polyp and 35 cases of IBS admitted from May 2012 to April 2014 were recruited;95 healthy volunteers were served as controls. Serum samples were collected to test specific IgE antibodies derived from 20 common inhalant and alimentary allergens by EUROIMMUN blotting test. Results:The positivity rates of allergen specific serum IgE antibodies in intestinal polyp group,IBS group and both two groups were 56. 67% ,74. 29% and 63. 16% ,respectively,all were significantly higher than that in control group(6. 32% ,P all <0. 05),but no statistically significant difference was seen between intestinal polyp group and IBS group(P > 0. 05). In all the 20 allergens tested,the positivity rates of Dermatophagoides,roach,crab,sea fish,freshwater fish,shrimp,and egg albumin specific serum IgE antibodies were significantly higher in patients group than in control group( P < 0. 05), especially the crab,see fish and Dermatophagoides specific IgE antibodies. Conclusions:Allergic factor might have some association with intestinal polyp and IBS.%背景：累及胃肠道的过敏性疾病主要是嗜酸细胞性胃肠炎，一些功能性胃肠病与过敏原亦存在关联。目前尚未明确肠息肉的发生是否与过敏因素有关。目的：探讨过敏因素与肠息肉和肠易激综合征（IBS）的关系。方法：收集2012年5月-2014年4月住院肠息肉患者60例、IBS 患者35例和同期健康志愿者95名，采集血清样本，以欧蒙印迹法检测20种常见吸入性和食物性过敏原特异性 IgE 抗体。结果：肠息肉组、IBS 组和两组总体血清过敏原特异性 IgE 抗体阳性率均显著高于对照组（56.67%、74.29%和63.16%对6.32%，P 均<0.05），两组患者组间差异无统计学意义（P >0.05）。患者组血清尘螨组合、蟑螂、蟹、海鱼组合、淡水鱼组合、虾、鸡蛋白特异性 IgE 抗体阳性率显著高于对照组（P <0.05），以蟹、海鱼组合、尘螨组合为著。结论：过敏因素与肠息肉和 IBS 之间可能存在一定关联。
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