Objective To discuss the related factors of Alzheimer's disease (AD). Methods 121 cases in accord with the diagnostic , inclusive and excluded criterion of AD were selected in case group compared with the control cases without the attack of AD which belong to control group. The 1: 1 matched case-control study was carried out which had the same sex and age, equal education degree. The survey method was faee-to-face interviews. Results Compared with the ones in control groups, the differences of high and low anger traits of the subjects in case group had statistical significances ( P < 0. 01). The frequency of physical exercise and recreational activities in case group were obviously lower than those in control group (P <0. 01). The satisfaction of social environment in case group was lower compared with that of control group ( P < 0. 05 ). The probability of the subjects with the family history of AD suffered from AD was higher compared with that of control group (P <0. 01). Conclusions High trait anger, family history of AD and history of cerebral trauma are the risk factors of AD, there are protective factors of AD, which include participating in physical exercise and recreational activities frequently, family harmony , life satisfaction of their own.%目的 探讨阿尔茨海默病(AD)发病相关因素.方法 病例组为121例符合AD诊断及纳入排除标准者,以非AD者为对照,采用同性别、同年龄、同教育程度1:1匹配的病例对照研究,调查方式为面对面访谈.结果 病例组高特质怒例数高于对照组(P＜0.01)；病例组健身锻炼及娱乐活动的频率均低于对照组(P＜0.01)；病例组生活满意度低于对照组(P＜0.05),阳性家族史患病高于对照组(P＜0.01).结论 高特质怒、家族AD病史、头部外伤史是AD发病的危险因素；健身锻炼和娱乐活动、对自身生活满意是AD发病的保护因素.
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