ObjectiveTo investigate the variability of Apelin-12 protein in patients with essential hypertension (EH) after and before taking the aerobic exercises and discuss the potential treatment principle on hypertension.Methods 80 subjects, aged 32~59, with moderate EH are randomly classified into two groups, one aerobic group, the other control group and all subjects' Apelin-12 protein and angiotensinⅡ (AngⅡ) are measured. Aerobic group has 12-week aerobic exercises and control group maintain the same lifestyle. 12 weeks later, the amount of Apelin-12 protein and AngⅡ is measured and data analysis are discussed.Results After doing 12 week-aerobic exercise, the blood pressure of patients with EH is decreased and there is a signiifcant increase in Apelin-12 protein (P<0.05) and an obvious decrease in AngⅡ (P<0.05) compared with the control group, whose Apelin-12 protein and AngⅡ remain unchanged. There is a negative correlation between the changes of Apelin-12 and AngⅡ in aerobic group.Conclusion Aerobic exercises are likely to decrease blood pressure of patients with EH through boosting Apelin and decreasing AngⅡ in the plasma.%目的：通过研究原发性高血压患者有氧运动前后血浆Apelin-12蛋白的变化，探讨运动降血压的可能机理。方法选取80例32～59岁轻中度原发高血压患者随机分成运动组和对照组，实验前测定两组血浆Apelin-12蛋白和血管紧张素Ⅱ（AngⅡ）水平，然后运动组完成12周有氧运动，对照组则保留原有生活习惯，然后再测定两组血浆Apelin-12和AngⅡ水平，将获得的数据进行统计学处理。结果12周有氧运动后原发性高血压患者血压较运动前降低；血浆Apelin-12水平较运动前显著升高（P＜0.05），与之相反，血浆Ang Ⅱ水平较运动前显著降低（P＜0.05），且运动组血浆Apelin-12和Ang Ⅱ变化水平呈负相关；对照组实验前后血浆Apelin-12和Ang Ⅱ则无明显变化。结论有氧运动可以下调原发性高血压患者血压，可能是通过提高血浆Apelin水平，下调AngⅡ水平，从而发挥下调血压的作用。
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