目的:观察妊娠期罹患感染性疾病以及孕期使用抗生素对妊娠结果的影响,研究分析妊娠期使用抗生素的安全可行性.方法:随机选取2014年1月至2015年12月在重庆三峡中心医院和四川绵阳四○四医院就诊以及分娩的妊娠期妇女426例中,依据随机数列法选取45例妊娠期感染性疾病妇女纳入病例组,并依据抗生素使用情况再次分为A组、B组.A组为23例接受抗生素治疗的妊娠期妇女,B组为22例未接受抗生素治疗的妊娠期妇女.对照组为45例健康的妊娠期妇女.分别比较各组的妊娠结果以及抗生素对妊娠结果的影响.结果:(1)妊娠期妇女罹患感染以及发热为致使不良妊娠结果的高危因素,可以导致胎儿流产、早产、生长发育不良、胎儿停止发育、胎死腹中、出生后体重较轻、新生儿畸形等缺陷.(2)妊娠期妇女感染未接受抗生素治疗组不良妊娠结果的发生率明显高于接受抗生素治疗组以及对照组,差异有统计学意义(P＜0.05).接受抗生素治疗的罹患感染性疾病的妊娠期妇女各个方面指标与对照组相比,结果无明显的差异,差异无统计学意义(P＞0.05).结论:妊娠期妇女罹患感染性疾病以及发热是致使不良妊娠结果的危险因素,可以导致胎儿流产、早产、生长发育不良、胎儿停止发育、胎死腹中、出生后体重较轻、新生儿畸形以及患感染性疾病等缺陷.接受抗生素治疗可以有效的降低不良妊娠结果的发生率,减少成活新生儿缺陷的发生率.%Objectives:To investigate the influence of infectious diseases and the use of antibiotics during pregnancy on pregnancy outcome,in order to provide reference for the safe usc of antibiotics during pregnancy.Methods:45 pregnant women among the 426 ones treated in Chongqing Three Gorges Central Hospital and Sichuan Mianyang 404 Hospital for infectious diseases from January 2014 to December 2015 were randomly selected and divided into group A and group B according the use of antibiotics.Group A (n =23) received antibiotics in pregnancy while group B (n =22) not.Another 45 healthy pregnant women were selected as control group.The pregnancy outcomes and influence of antibiotics on pregnancy outcomes were compared.Results:① Infectious diseases and fever were risk factors of adverse pregnancy outcomes that might lead to miscarriage,premature birth,poor growth and development,fetus stopping growing,stillbirth,low birth weight,birth defects and other defects.② The incidence of adverse pregnancy outcomes of group B was higher than group A and control group,with statistically significant difference (P ＜ 0.05).There was no significant difference in each indictor between pregnant women in group A and the control group,without statistically significance (P ＞ 0.05).Conclusion:Infectious diseases and fever are risk factors causing adverse pregnancy outcomes,which can lead to miscarriage,premature birth,poor growth and development,the fetus stopping growing,stillbirth,low birth weight,and neonatal malformations and other defects.Antibiotic treatment can effectively reduce the incidence of adverse pregnancy outcomes and the incidence of birth defects.
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