目的:探讨不同微导管超选择插管对于子宫肌瘤介入后生活质量的影响.方法:子宫肌瘤育龄女性180例根据随机抽签方法分为治疗组与对照组各90例,都给予导管插管栓塞治疗,治疗组选用聚乙烯醇颗粒进行插管栓塞,对照组选择平阳霉素碘化油乳剂插管栓塞.结果:治疗后治疗组与对照组的有效率分别为96.7％和94.4％,两组疗效都比较高,对比差异无统计学意义(P＞0.05).两组治疗前后的血清FSH、LH与E2值对比差异无统计学意义(P＞0.05),同时组间对比差异也无统计学意义(P＞0.05).治疗后经过观察,治疗组的盆腔感染、闭经、恶心呕吐等并发症总体发生率明显少于对照组.治疗组的躯体化、人际关系、抑郁、焦虑评分明显高于对照组,对比差异都有统计学意义(P＜0.05).所有患者治疗后随访1年,经过观察,治疗组的半年复发率明显低于对照组,对比差异有统计学意义(P＜0.05).结论:介入治疗在改善子宫肌瘤症状以及缩小肌瘤方面有着显著的疗效,对内分泌激素影响小,采用聚乙烯醇颗粒进行导管插管的安全性更加好,短期复发率低.%Objectives:To study the effects of different microcatheter superselective catheterization for the quality of life of uterine fibroids patients after interventional therapy.Methods:180 uterine fibroids patients at childbearing age were randomly divided into the treatment group and the control group with 90 cases in each group.All were given catheter embolization therapy.The treatment group received polyvinyl alcohol particles embolization,while the control group received Pingyang mycin lipiodol emulsion embolization.Results:After treatment,the effective rate of treatment group and control group was 96.7％ and 94.4％ respectively,without statistically significant difference (P ＞ 0.05).Serum FSH,LH and E2 before and after treatment in two groups were of no significant difference (P ＞ 0.05),so as the difference between the groups (P ＞ 0.05).After treatment,the incidece of pelvic infection,amenorrhea,nausea and vomiting complications in treatment group was significantly less than that of the control group.The incidence of somatization,interpersonal relationship,depression,anxiety score was significantly higher than that in the control group,with statistically significant differences (P ＜ 0.05).In the one year follow-up,the recurrence rate in the first half year of the treatment group was lower than that in control group,with statistically significant difference (P ＜ 0.05).Conclusion:Interventional therapy is of remarkable curative effect in the improvement of myoma of uterus and reducing leiomyoma,with little influence on endocrine hormone.Using catheterization with polyvinyl alcohol particles is safer with low recurrence rate.
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