目的：探讨CO2激光单次治疗女性尖锐湿疣的临床疗效及其预后影响因素分析。方法：回顾性分析2009年1月至2011年12月在云浮市慢性病防治中心接受CO2激光治疗的128例尖锐湿疣患者的临床资料，术后对患者随访2年，观察其临床疗效，并对影响预后的相关因素采用Logistic回归分析。结果：128例患者CO2激光单次治愈88例（68.80％），2次治愈27例（21.10％），2次以上治愈5例（3.90％），未治愈8例（6.30％），总治愈率为120例（93.80％）。治疗过程中共有48例患者发生不良反应，不良反应率为37.50％，均属轻度不良反应。经单因素分析可知，性伴侣个数、临床症状、病变面积、阴道受累、尿道受累、病程、学历、收入状况、社保情况均是影响患者CO2激光单次治愈效果的相关因素，经Lgositic多因素排除相关的影响因素后，病变面积、阴道受累、尿道受累、收入情况、性伴侣个数是影响CO2激光单次治愈效果独立危险因素。结论：CO2激光单次治疗女性尖锐湿疣是安全有效的，影响其单次治疗效果的危险因素包括病变面积、阴道受累、尿道受累、收入情况，因此术后应加强对收入低、病变面积范围大、阴道受累及尿道受累患者的随访及辅佐治疗，从而提高该部分患者CO2激光单次治愈率，减少患者治疗费用。%To investigate the clinical efficacy and prognostic factors of the CO2 laser in the treatment of female genital warts.Methods:The clinical data of 128 patients with genital warts in the Center from January 2009 to December 2013 were retrospectively analyzed.All patients were followed up for 2 years.The influ-encing factors were analysised with Logistic regression analyses.Results:Of the 128 patients,88 ones (68.80%) were cured with single CO2 laser;27 ones (21.10%)were cured with twice CO2 laser;five cases (3.90%)were cured with two or more times;8 cases (6.30%)were not cured,with total cure rate of 93.80%(120 cases).48 patients incurred mild adverse reactions during treatment with adverse reaction rate of 37.50%.Univariate analysis showed that the number of sexual partners,clinical symptoms,lesion area,vaginal involvement,urethral involve-ment,course,education,income,social security conditions were all influencing factors of patients’healing effects with single CO2 laser;after irrelevant factors being excluded with Lgositic analysis,the lesion area,vaginal involve-ment,urethral involvement,income,number of sexual partners were indentified as independent risk factors affecting healing effects of single CO2 laser.Conclusion:Single CO2 laser is safe and effective in treating female genital warts,and affecting factors include treatment lesion area,vaginal involvement,urethral involvement,income. Therefore,follow-up and adjuvant treatment should be strengthened for patients with low income,large lesion area range,vaginal and urethral infection,thereby improving the single cure rate of CO2 laser in some patients and re-ducing the treatment cost of patients.
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