Objective To observe the analgesic effect of collective use of external analgesic cataplasm acupoint sticking and internal Yiqi-dose on H22 tumor-bearing mice, and explore its underlying mechanism. Methods Fifty Kunming female mice were randomly divided into blank group, model group,dose group, acupoint sticking group and collective use group. Blank group and model group were given normal saline, other groups were given corresponding treatment. The pain threshold of the H22 tumor-bearing mice before and after 30 minutes of the treatment was measured, and the improvement of it was compared. Results Collective use, analgesic cataplasm or Yiqi-dose could raise pain threshold of the H22 tumor-bearing mice at different level. The pain threshold level of dose group or collective use group has significant difference compared with blank group (P ＜0.01). Conclusion External analgesic cataplasm acupoint sticking combined with internal Yiqi-dose can raise pain threshold level and its percentage of H22 tumor-bearing mice.%目的 观察化积止痛巴布剂穴贴配合益气化积方内服对H22荷瘤小鼠镇痛作用的影响,探讨其作用机理.方法 昆明种雌性小鼠50只,随机分为空白组、模型组、药物组、穴贴组、药物加穴贴组.空白组灌服生理盐水并穴贴无药涂膏,不接种瘤株;其余各组接种瘤株后,模型组灌服生理盐水并穴贴无药涂膏;药物组灌服中药益气化积方并穴贴无药涂膏;穴贴组灌服生理盐水并穴贴化积止痛巴布剂;药物加穴贴组灌服中药益气化积方并穴贴化积止痛巴布剂;连续用药14 d.末次用药后30 min,测定小鼠痛阈值,并计算痛阚提高百分率.结果 药物加穴贴组、药物组及穴贴组能够不同程度提高小鼠的痛阁值和痛阈提高百分率,其中药物加穴贴组及药物组的痛阈与空白组和给药前的痛阈比较均具有明显变化(P＜0.01).结论 化积止痛巴布剂穴贴配合益气化积方内服能增加H22荷瘤小鼠的痛阈l值及提高痛阈百分率.
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