制备了一个芳酰腙化合物4-氟-N'-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼(H2L).利用H2L和VO(acac)2分别与甲基麦芽酚(mat)和乙基麦芽酚(Emat)在甲醇中反应,得到了2个配合物[VO(L)(mat)](1)和[VO(L)(Emat)](2).通过元素分析、红外光谱、紫外可见光谱和核磁共振氢谱表征了这些化合物的结构.通过单晶X射线衍射进一步确定了化合物的结构.芳酰腙配体以二价阴离子的方式通过酚羟基氧、亚胺基氮和烯醇氧原子与钒原子进行配位.在每个配合物中,钒都采取八面体配位构型.将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这两个配合物在剂量为10.0和20.0 mgv·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而对于正常大鼠的血糖值却没有改变.%A new aroylhydrazone compound 4-fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide (H2L) was prepared.Reaction of H2L and VO(acac)2 with maltol(mat) and ethylmaltol(Emat),respectively,in methanol afforded the complexes [VO(L)(mat)] (1) and [VO(L)(Emat)] (2).Both H2L and the oxovanadium complexes were characterized by elemental analysis,IR,UV-Vis and 1H NMR spectra.The structures of the compounds were further confirmed by single crystal X-ray diffraction.The aroylhydrazone ligand,in its dianionic form,coordinated to the V atoms through the phenolate oxygen,imino nitrogen and enolate oxygen.The mahol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen.The V atom in each complex is in octahedral coordination.The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks.The biological activity results show that the complexes at doses of 10.0 and 20.0 mgv ·kg-1,can significantly decrease the blood glucose level in alloxan-diabetic mice,but the blood glucose level in the treated normal mice was not altered.
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