磷氨米酮是从链霉菌培养液中分离得到的一种天然磷酰糖肽。作为多种金属蛋白酶的抑制剂,磷氨米酮在生物和医学领域有着广泛的应用。该研究通过对化学合成磷氨米酮及其β-端位异构体的1D NMR波谱(1H,13C和31P NMR)和2D NMR波谱(1H-1H COSY, HSQC和NOESY)的解析,对其NMR信号进行了全归属,并确认了磷氨米酮及其β-端位异构体的端位构型。%Phosphoramidon is a naturally occurring glycopeptide isolated from the culture of Streptomyces tanashiensis. As an inhibitor of metalloproteases, phosphoramidon has many important applications in biological and medicinal research. On the basis of one-dimensional (i.e., 1H, 13C, and 31P) and two-dimensional (i.e., 1H-1H COSY, HSQC, and NOESY) NMR spectral data, the NMR signals for phosphoramidon and itsb-anomer were assigned. The anomeric configurations of the two isomers were determined.
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