Objective To explore the feasibility of real-time ultrasonic elasticity quantitative for diagnosing alcoholic liver fibrosis, and to screen sensitive parameters through assessing the diagnostic value of them. Methods Eighty-five patients with long-term drinking history who underwent real-time ultrasonic elasticity quantitative examination were retrospectively analyzed, and the results of liver fibrosis staging according to quantitative parameters were compared with those of pathology. Results MEAN and AREA had significant correlation with pathological staging of liver fibrosis (r=-0. 83, 0. 85, P <0. 01). Along with the staging increased, MEAN gradually reduced, while AREA increased, and all the differences had statistical significance (all P<0. 05). The areas under ROC curves of MEAN and ARER were all ≥0. 90. Conclusion Real-time ultrasonic elasticity can quantitatively diagnose alcoholic liver fibrosis. AREA and MEAN can assess the staging of liver fibrosis sensitively.%目的 探讨实时超声弹性定量诊断酒精性肝纤维化的可行性,筛选敏感参数,并评价其诊断价值.方法 回顾分析85例长期饮酒患者的实时超声弹性定量图及定量参数,并与肝纤维化病理分期进行相关分析.结果 应变均值(MEAN)、蓝色区域百分比(AREA)与肝纤维化病理分期高度相关(r=-0.83、0.85,P＜0.01).随着肝纤维化分期增加,MEAN逐渐减少,AREA逐渐增加,各分期间差异有统计学意义(P＜0.05).MEAN和AREA在各分期的ROC曲线下面积均≥0.90.结论 实时超声弹性可定量诊断酒精性肝纤维化；AREA、MEAN是评估肝纤维化分期的敏感的定量参数.
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