目的 探讨TTE联合双源CT观察纯合子型家族性高胆固醇血症(HoFH)患者主动脉根部钙化的价值及钙化斑块对主动脉及冠状动脉血流动力学的影响.方法 采用TTE联合双源CT观察20例HoFH患者主动脉根部是否存在钙化、管腔狭窄情况及钙化斑块是否累及冠状动脉开口,并测量冠状动脉血流速度储备(CFVR).结果 经TTE联合双源CT检查,20例患者均有主动脉根部钙化,其中10例患者因钙化斑块引起主动脉管腔狭窄.主动脉根部钙化斑块累及冠状动脉开口者CFVR为1.72±0.32,低于未累及冠状动脉开口者(2.23±0.26,P＜0.05).结论 TTE联合双源CT能准确评价HoFH患者主动脉根部钙化.%Objective To investigate the value of TTE combined with dual-source computed tomography (DSCT) in observing calcification in aortic root and the influence of calcified plague on coronary artery hemodynamics in patients with ho-mozygote familial hypercholesterolemia (HoFH). Methods TTE combined with DSCT were performed on 20 patients with HoFH. Whether there was calcified plague in aortic root, as well as whether the calcification involved ostia of coronary artery and the situation of vessel stenosis were analyzed. And the coronary flow velocity reserve (CFVR) was calculated. Results Calcification in aortic root was found in all the patients with TTE combined with DSCT, while 10 of them had aortic stenosis caused by calcified plague. Calcified plague involved ostia of coronary artery in 9 patients. CFVR of calcified plague involved ostia of coronary artery patients (1. 72 ± 0. 32) was lower than that of uninvolved patients (2. 23 ± 0. 26, P< 0. 05). Conclusion TTE combined with DSCT can accurately evaluate aortic root calcification in patients with HoFH.
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