目的 探讨声脉冲辐射力成像(ARFI)技术定量检测慢性肝病肝纤维化的价值.方法 研究对象包括61例乙型肝炎病毒阳性患者(慢性肝病组)、29例肝硬化患者(肝硬化组)及109名健康对照者(对照组).采用ARFI技术定量测量肝实质剪切波速度.结果 慢性肝病组、肝硬化组、对照组肝脏平均剪切波速分别为(1.59±0.38)m/s、(2.35±0.53)m/s、(1.11±0.18)m/s,两两比较差异均有统计学意义(P＜0.05).结论 ARFI可无创测量肝实质剪切波速度,客观反映肝组织的弹性模量,有望成为定量评估肝纤维化的客观准确的新方法.%Objective To explore the value of acoustic radiation force impulse (ARFI) in quantitative assessment of liver fibrosis. Methods Totally 61 patients with HBV infection and 29 with liver cirrhosis were enrolled, and 109 healthy people were regarded as control group. ARFI was performed to measure the velocity of shear wave in liver tissue. Results The average velocity of shear wave was (1. 59±0. 38)m/s, (2. 35±0. 53)m/s, (1. 11±0. 18) m/s in HBV infection, liver cirrhosis and control group, respectively. Significant differences were found among these three groups (P<0. 05). Conclusion ARFI technique can measure the velocity of shear wave in liver tissue non-invasively, and provide a new feasible and accurate way to quantitatively evaluate liver cirrhosis.
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