Objective:To analyze and compare differences in macular thickness of pseudoexfoliation glaucoma (PXG),pseudoexfoliation syndrome (PEX),and age-matched control (CON) subjects.Methods:This clinical case control study was conducted from May 2014 to May 2017,and the patients were selected consecutively.The PXG group included 31 eyes of 31 cases,the PEX group included 16 eyes of 16 cases,and the CON group included 34 eyes of 34 subjects that were age and gender-matched.All subjects underwent three-dimensional optical coherence tomography scans to measure macular thickness and macular volume.The data were analyzed by ANOVA.Results:The average macular thicknesses of CON group,PEX group,and PXG group were 305± 15 μm,299± 12 μm,and 289± 18 μm,respectively.The average macular volume of the three groups were 0.94±0.05 μmm3,0.92±0.03 μmm3,and 0.89±0.06 μm3 respectively.The overall difference of macular thickness in nasal inner macula (NIM),superior inner macula (SIM),temporal inner macula (TIM),inferior inner macula (IIM),superior outer macula (SOM),temporal outer macula (TOM),and inferior outer macula (IOM) quadrants was significant among the three groups (F=4.887,8.987,7.889,9.489,6.462,6.464,and 7.964,P＜0.05).However,there were no significant differences among the central macular thickness (CMT),central subfield (CSF),and nasal outer macula (NOM) quadrants.The overall difference of macular volume in NIM,SIM,TIM,IIM,SOM,TOM,and IOM quadrants was significant among the three groups (F=4.352,8.697,7.920,8.513,6.185,6.411,9.095,P＜0.05).However,there were no significant differences between the CSF and NOM quadrants.The macular thickness of the PXG group was thinner than in the CON group in the NIM,SIM,TIM,IIM,NOM,SOM,TOM,and IOM quadrants (P＜0.05).The macular volumes of the PXG group were smaller than in the CON group in the NIM,SIM,TIM,IIM,NOM,SOM,and IOM quadrants of (P＜0.05).The macular thicknesses and macular volumes of the PXG group were thinner or smaller than in the PEX group for the SIM,IIM,and SOM quadrants (P＜0.05).Conclusions:The macular thickness and volume becomes thinned in PXG,and monitoring the changes can provide important information for making a diagnosis of PXG.%目的:对比分析剥脱性青光眼(PXG)、剥脱综合征(PEX)患者及正常人(CON)黄斑厚度及体积的差异.方法:病例对照研究.连续性选取2014年5月至2017年5月在石家庄市第一医院住院治疗的PXG病例31例(31眼),PEX病例16例(16眼)及性别、年龄相匹配的CON 34例(34眼)分别作为PXG组、PEX组、CON组.3组纳入人员均进行黄斑区OCT-3D模式扫描,并对黄斑各区厚度及体积进行单因素方差分析.结果:CON组、PEX组、PXG组黄斑平均厚度分别为(305±15)μm、(299± 12)μm、(289± 18) μm,黄斑平均体积分别为(0.94±0.05)μm3、(0.92±0.03) μm3、(0.89±0.06)μm3.3组间黄斑厚度总体差异在鼻内环(NIM)、上内环(SIM)、颞内环(TIM)、下内环(IIM)、上外环(SOM)、颞外环(TOM)、下外环(IOM)区有统计学意义(F=4.887、8.987、7.889、9.489、6.462、6.464、7.964,P＜0.05),在中心凹厚度(CMT)、中央区(CSF)、鼻外环(NOM)区差异无统计学意义;3组间体积总体差异在NIM、SIM、TIM、IIM、SOM、TOM、IOM区有统计学意义(F=4.352、8.697、7.920、8.513、6.185、6.411、9.095,P＜0.05),在CSF、NOM区差异无统计学意义.进一步两两比较显示,PXG组与CON组相比,黄斑厚度在NIM、SIM、TIM、IIM、NOM、SOM、TOM、IOM区变薄(P＜0.05);黄斑体积在NIM、SIM、TIM、IIM、NOM、SOM、IOM区变小(P＜0.05).PXG组与PEX组相比,黄斑厚度及体积在SIM、IIM、SOM区变薄(P＜0.05).结论:与PEX患者及正常人相比,PXG患者黄斑厚度变薄、体积变小,监测黄斑厚度的变化对PXG的临床诊治具有重要意义.
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