Objective To study the application value of three dimensional-T2 weighted imaging-sampling perfection with application optimized contrasts using different flip angle evolutions (3D-T2WI-SPACE) sequence in carotid high-resolution magnetic resonance imaging (MRI). Methods Thirty patients with suspected carotid disease were recruited in this study. High-resolution multicontrast MRI was performed using 3.0T MRI with a 4-channel surface carotid coil. 3D-T2WI-SPACE sequence was applied by coronal plane; and oblique saggital and axial images were reconstructed using post-processing software. Signal-to-noise ratio, image quality of 3D-T2WI-SPACE sequence and axial high-resolution T2WI sequence, as well as scan coverage and diagnostic information were compared. Results Among all sixty carotids, thirteen vessels are normal, and forty-four carotids were found plaques; one was carotid dissection; and two were idiopathic stenosis. For the image quality of 3D-T2WI-SPACE sequence and T2WI sequence, there were 5 cases and 4 cases with II grade, and 25 cases and 26 cases with III grade, respectively. 3D-T2WI-SPACE can provide more diagnostic information than T2WI. The coverage of SPACE and T2WI sequence were (114.7±22.4) mm and 46 mm, respectively. There was no signiifcant difference between signal-to-noise ratio of 3D-T2WI-SPACE (15.7±3.5) and T2W (22.7±14.7) (P=0.163). Conclusion 3D-T2WI-SPACE sequence can be used as an important sequence in carotid high-resolution MRI. This 3D sequence can provide large scan coverage and more important information for carotid imaging.%目的：探讨三维T2可变翻转角加权快速自旋回波成像技术（three dimensional-T2 weighted imaging-sampling perfection with application optimized contrasts using different flip angle evolutions，3D-T2WI-SPACE）序列在颈动脉高分辨率磁共振成像中的应用价值。方法收集临床怀疑颈动脉病变患者30例，进行高分辨多对比颈动脉磁共振成像（magnetic resonance imaging，MRI），行冠状位3D-T2WI-SPACE序列并应用3D后处理软件进行斜矢状位和轴位重建。比较3D-T2WI-SPACE序列和横轴位黑血T2WI序列的信噪比及图像质量，并对图像成像范围、对病变诊断信息提供的充分程度进行比较。结果60支颈动脉中，正常13支，病变47支。其中颈动脉粥样硬化病变44支，颈动脉夹层1支，不明原因的特发性狭窄2支。30例病例图像质量评价中，3D-T2WI-SPACE序列图像质量2级5例，3级25例；T2WI序列图像质量2级4例，3级26例。3D-T2WI-SPACE序列对诊断信息提供的充分程度略优于高分辨T2WI。3D-T2WI-SPACE序列与高分辨率T2WI图像的覆盖范围分别为（114.7±22.4）mm和46 mm。3D-T2WI-SPACE序列图像与高分辨T2WI的信噪比平均值分别为15.7±3.5及22.7±14.7，差异无显著性（P=0.163）。结论3D-T2WI-SPACE技术可作为颈动脉高分辨成像序列中的必要辅助序列。应用3D-T2WI-SPACE序列结合重建技术，可为临床诊断提供更多信息。
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