A series of novel dipeptidyl peptidase Ⅳ inhibitors(6a ～6j) bearing multi fluorine atoms were designed and synthesized. The structures were characterized by 1H NMR and ESI-MS. Their anti-hyperglycemic activities were evaluated through in vivo oral glucose tolerance test in mice. The resuits showed that 6c and 6h were found to be comparable with the positive control sitagliptin.%设计并合成了一系列含多氟的4-甲基噻唑环的新型二肽基肽酶Ⅳ抑制剂(6a～6i),其结构经1H NMR和ESI-MS表征.以西他列汀为阳性对照药,采用小鼠体内口服葡萄糖耐受量法测试,结果显示6c和6h具有明显的降血糖作用.
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