叔丁基[1-(对溴苯基)环丁基]氨基甲酸酯与N-甲基-N-甲氧基-苄酰胺在正丁基锂的作用下,经Weinreb 酮合成法合成了抗癌药物二氮杂萘衍生物的关键中间体——叔丁基{1-[(对苯乙酰基)苯基]环丁基}氨基甲酸酯,收率33％,其结构经1H NMR确证.%A key anti-cancer drug intermediate, t-butyI{1-[(p-phenylacetyl)phenyl]cyclobutyl|car-bamate, was synthesized in yield of 33% by the Weinreb ketone synthesis method of t-butyl[1-(p-bromophenyl)cyclobutyl] carbamate with N-methyl-N-methoxy-2-phenyIacetainide in the presence of n-BuLi. The structure was confirmed by 1 H NMR.
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