BACKGROUND: A variety of angiogenic factors are involved in bone healing after osteonecrosis of the femoral head. OBJECTIVE:To explore the role and mechanism of angiogenic factors in osteonecrosis of the femoral head. METHODS: A computed-based online search of PubMed, Google and SpringerLink databases was performed using the key words of “angiogenic factors, osteonecrosis of the femoral head, vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, hypoxia inducible factor-1, calcitonin gene related peptide and hypoxia inducible factor-1α” for literatures published from December 1980 to May 2015. RESULTS AND CONCLUSION:Finaly, 68 articles were included. Bone angiogenesis which is dependent on special signaling factors in the microenvironment is closely linked with bone repair. A variety of cytokines, such as vascular endothelial growth factor, angiopoietin-1, fibroblast growth factor-2, platelet-derived growth factor, calcitonin gene-related peptide, and hypoxia inducible factor-1α, have been identifiedto control angiogenesis in different ways and be involved in the repair of necrotic femoral head.%背景：多种血管生长细胞因子参与损伤股骨头的愈合。 目的：探索血管生长细胞因子在股骨头坏死中的作用及其作用机制。 方法：应用计算机检索1980年11月至2015年5月PubMed数据库、Google数据库和SpringerLink数据库中的相关文章，检索词为“angiogenic factors， osteonecrosis of the femoral head， vascular endothelial growth factor， angiopoietin-1，fibroblast growth factor-2，hypoxia inducible factor-1， calcitonin gene related peptide and hypoxia inducible factor-1α”。 结果与结论：最终纳入符合标准的文献68篇。骨血管化和骨修复关系密切，而血管化是基于微环境内特定的信号因子。血管内皮生长因子、血管形成素1、纤维生长因子2、血小板衍生生长因子、降钙素基因相关肽、缺氧诱导因子α等血管生长细胞因子已被证实从不同途径调控股骨头中血管化过程，且对股骨头坏死区域修复有重要的作用。
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