Objective To analyze the imaging characteristics of contrast-enhanced ultrasound(CEUS) in alpha-fetoprotein(AFP) negative recurrent hepatocellular carcinoma(RHCC).Methods CEUS was concluded in 65 patients with 76 lesions of AFP negative RHCC and 91 patients with 111 lesions of AFP positive RHCC.The hemodynamic parameters in the forms of enhanced beginning time,time to peak intensity,time to fade,time to hypo enhancing of these two groups were analyzed and compared.Results Compared with AFP positive group the enhanced peak time,and the time when the physical sign of fading away and the time to hypo enhancing in AFP negative group were significantly increased(P＜0.05).The were 50(65.8％),30(39.5％)cases of AFP negative RHCC and 43(38.7％),9(8.1％) case of AFP positive RHCC becoming isoehancing during the portal and late phases,the former rate was significantly higher than the late one(P＜0.05).Conclusions The perfusion pattern of AFP negative RHCC CEUS is still prior to fast forward retreat quickly,but also presents the diversification trend.Studied the enhancement patterns maybe provides a convenient and valuable method for the early diagnosis of AFP negative RHCC.%目的 观察分析甲胎蛋白(AFP)阴性复发性肝细胞癌(RHCC)病灶超声造影影像学特征.方法 对AFP阴性RHCC患者65例76个病灶和AFP阳性RHCC患者91例111个病灶进行超声造影,分析比较两组间超声造影开始增强时间、达峰时间、开始消退时间、低增强开始时间及灌注模式等血流动力学参数.结果 AFP阴性组与AFP阳性组比较,达峰时间、开始消退时间及低增强开始时间的差异均有统计学意义(P＜0.05).AFP阴性RHCC在门脉期和延迟期中表现为等增强的比例均明显高于AFP阳性RHCC (P＜0.05).结论 AFP阴性RHCC超声造影灌注仍以快进快退为主,但与AFP阳性RHCC表现有一定的差异,呈现出多样化趋势,认识这一规律有可能为临床提供一个简便且有一定参考价值的诊断方法.
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