Objective To investigate the possible correlation between carotid artery calcification score (CS) and cognitive impairment of carotid artery stenosis (CAS) patients. Methods Carotid artery plaque volume was measured in 123 carotid arteries using multi-detector computer tomography angiography and magnetic resonance imaging, we measured the CS of each sample and divided them by recognition examination and degree of luminal stenosis. Together with other risk factors for cognitive impairment including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia and body mass index, the CSs had been analyzed by Kruskal-wallis test for their association with cognitive function. Correlation analysis was launched between MRI parameters、cognitive scores and CS. Follow-up review analysis was operated on 38 postoperative patients. Results In the Kruskal-Wallis analysis of CSs between groups divided by degree of cognitive impairment and luminal stenosis, the results both showed significantly difference (P<0.001). Significant correlation was discovered with CS and cognitive scores in patients with carotid artery stenosis ( P<0.001), while the correlation did not exist within postoperative patients(P=0.348). It was shown the correlation between CS and MRI parameters in pre-operative patients. Conclusion Carotid artery calcification scores show significant correlation with cognitive impairment and the degree of stenosis, which can be used as an independent risk factor for early screening. The possible mechanism may be related to the calcification-impact on the stability of the plaques.%目的 探讨颈动脉狭窄(CAS)患者的钙化积分(CS)与其认知障碍关联性及其可能机制.方法 通过对123例CAS患者行多层螺旋CT扫描,计算患者颈动脉斑块内CS,同时通过磁共振扫描采集患者脑灌注参数[相对脑血流量(rCBF)、相对脑血容量(rCBV)、相对平均通过时间(rMTT)、血流达峰时间TTP)及血流到达时间(TO)].将所有患者按认知障碍程度和CAS程度分组,将所测得CS数据与认知潜在的常规危险因子(年龄、性别、高血压、糖尿病、高血脂、吸烟史及体重指数)一并进行分组对比差异性分析,同时对同一患者的认知评分、磁共振灌注参数与CS进行关联性分析,并对术后38例患者进行随访分析.结果 与年龄、 高血压及糖尿病相似,CS值在不同认知功能的患者中具有显著差异性分布(P<0.001);与年龄、 性别、 高血压及糖尿病相似,CS值在不同CAS程度患者中具有显著差异性分布(P<0.001).患者的CS值与其认知评分存在显著相关性(P<0.001),术后随访患者CS值与认知评分无明确相关性(P=0.348);CS值与患者磁共振灌注参数中的rMTT、TTP及TO参数均存在显著相关性(P<0.001).结论 颈动脉CS与CAS患者的认知障碍及狭窄程度均存在显著相关性,可作为其独立危险因子,其机制可能与钙化对斑块稳定性的影响有关.
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