Objective To detect the expressions of RNA-binding proteins QKI-5 and Ezrin in serous ovarian carcinoma and to explore their correlation with the occurrence and development of serous ovarian carcinoma .Methods Forty patients with serous ovarian carcinoma diagnosed in Zhoushan Hospital of Zhejiang University from 2012 to 2017 and 20 normal women were enrolled in this study .Expressions of RNA-binding proteins QKI-5 and Ezrin in ovarian tissue samples were detected by immunohistochemistry , results were analyzed ,and correlation between them was explored .Results Expressions of QKI-5 mRNA and Ezrin in ovarian tissue in serous ovarian carcinoma patients were significantly down-regulated when compared with those in normal controls , and differences were statistically significant (t value was 2 .71 and 3 .72 ,respectively ,both P < 0 .05) .Ezrin positive rate in serous ovarian carcinoma patients was 97 .50% ,while positive rate of Ezrin in ovarian epithelial cells in normal controls was 100 .00% . There was no significant difference between two groups (χ2 = 0 .51 ,P = 0 .48) .Conclusion Down-regulation of expressions of RNA binding-proteins QKI-5 and Ezrin is closely related to pathological process such as tumor occurrence and development in serous ovarian cancer patients ,so these two indicators are expected to be early diagnostic indexes for ovarian cancer ,and they provide new ideas for clinical treatment of ovarian cancer patients .%目的 检测RNA结合蛋白QKI-5、Ezrin在浆液性卵巢癌中的表达,探讨其在浆液性卵巢癌发生发展中的作用.方法 选取2012年至2017年在浙江大学舟山医院就诊且诊断为浆液性卵巢癌的患者40例及正常女性20例为研究对象,采用免疫组化的方法对卵巢组织标本中的RNA结合蛋白QKI-5、Ezrin的表达进行检测,对结果进行分析,并比较两者之间的相关性.结果 与对照组相比,QKI-5 mRNA、Ezrin在浆液性卵巢癌患者卵巢组织中的表达均显著的下调,差异均具有统计学的意义(t值分别为2.71、3.72,均P<0.05).浆液性卵巢癌组织样品中Ezrin阳性率为97.50%,对照组卵巢上皮组织细胞中Ezrin阳性率为100.00%,两组之间比较无显著性差异(χ2=0.51,P=0.48).结论 RNA结合蛋白QKI-5、Ezrin的表达下调与浆液性卵巢癌患者肿瘤的发生发展等临床病理过程相关,这两个指标有望成为卵巢癌的早期诊断指标,并可能为卵巢癌患者临床治疗提供新思路.
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