目的探讨基质金属蛋白酶-2（MMP-2）、低氧诱导因子-1α（HIF-1α）在葡萄胎恶变的作用机理。方法对32例良性转归葡萄胎及14例恶性转变葡萄胎采用免疫组化法检测MMP-2、HIF-1α的表达水平，并对两者的相关性进行研究。结果MMP-2及HIF-1α在葡萄胎组织均有表达，但在恶性转归组的表达强于良性转归组（χ2值分别为4．563、5．139，均P＜0．05）；相关性分析结果显示，MMP-2的表达与HIF-1α的表达呈正相关（rs ＝0．627，P＜0．05）。结论 MMP-2和HIF-1α在葡萄胎恶性转变中起一定作用，用来预测葡萄胎的恶变可能有重要意义。%Objective To study the development mechanism of matrix metalloproteinase-2 ( MMP-2 ) and hypoxia-inducible factor-1α( HIF-1α) in malignant-transformed hydatidiform mole . Methods The expression of MMP-2 and HIF-1αwas detected by immunohistochemistry in 32 cases of remising-transformed hydatidiform mole and 14 cases of malignant-transformed hydatidiform mole .And the relationship between HIF-1αand MMP-2 was studied.Results Both MMP-2 and HIF-1αwere expressed, but the expression of MMP-2 and HIF-1αwas significantly higher in malignant-transformed hydatidiform mole than that in remising-transformed hydatidiform mole (χ2 value was 4.563 and 5.139, respectively, both P<0.05).Correlation analysis indicated that there was positive correlation between the expression of MMP-2 and HIF-1α(rs=0.627, P<0.05).Conclusion The expression of MMP-2 and HIF-1αcould be an useful index for prediction of malignant transformation of hydatidiform mole .
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