Objective To evaluate the application value of high-risk HPV-DNA and thinprep cytology test ( TCT ) in cervical cancer screening among postmenopausal women .Methods Total 346 postmenopausal women receiving common cervical screening in Nantong Maternity and Child Health Hospital were randomly selected to perform high-risk HPV-DNA and TCT check .The cases with positive results received pathological biopsy .Results The difference in sensitivity of HPV-DNA and TCT was not statistically significant (P>0.05).The positive prediction values of TCT and HPV-DNA were 19.05%and 44.64%, respectively, and the difference was statistically significant (χ2 value was 12.91AB and 12.17AC, respectively, both P<0.05).There was no significant difference between the double positive value of TCT combined with HPV and the positive predictive value of single HPV (P>0.05).Taking pathological diagnosis as gold standard , the positive coincidence rate of ASCUS , LSIL, HSIL and SCC was 5.56%, 27.03%, 40.00%and 85.71%, respectively.Conclusion The single high-risk HPV-DNA test can be used as the preferred method of cervical cancer screening among postmenopausal women .%目的评价高危型HPV-DNA和薄层液基细胞学检查（ TCT）在绝经后妇女宫颈癌筛查中的应用价值。方法随机选择南通市妇幼保健院参加宫颈普查的绝经后妇女346例，同时进行高危型HPV-DNA和TCT检查，发现阳性者即进行病理学活检。结果 HPV-DNA和TCT两种筛查方法的灵敏度比较，差异无统计学意义（P＞0．05）。 TCT及HPV-DNA两种筛查方法的阳性预测值分别为19．05％和44．64％，统计学上有显著差异（χ2值分别为12．91AB和12．17AC，P＜0．05），与TCT联合HPV筛查的双阳性结果比较，单独HPV筛查的阳性预测值差异无统计学意义（P＞0．05）。以病理诊断结果为金标准，ASCUS、LSIL、HSIL、SCC阳性符合率分别为5．56％，27．03％，40．00％，85．71％。结论单一高危型HPV-DNA检测可以作为绝经后妇女宫颈癌筛查的首选方法。
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