目的 探讨脂蛋白(a)、超氧化物歧化酶(SOD)、尿酸水平与妊娠期高血压疾病(HDCP)的关系.方法 用全自动生化分析仪检测67例HDCP患者血清中脂蛋白(a)、SOD和尿酸水平,根据病情分为妊娠期高血压组21例,轻度子痫前期组19例,重度子痫前期组27例;与50例孕周相近的正常单胎妊娠妇女(对照组)的血清脂蛋白(a)、SOD、尿酸水平进行比较分析.结果 ①HDCP各组血清脂蛋白(a)和尿酸水平均高于正常对照组,t值分别为-4.879、-7.410,均P<0.05,各组的SOD低于对照组,t=5.658,P<0.05;②妊娠期高血压组、轻度子痫前期组和重度子痫前期组孕妇的脂蛋白(a)逐渐升高,重度子痫前期与轻度子痫前期组比较,差异有统计学意义(t=-2.109,P<0.05),妊娠期高血压与轻度子痫前期组比较,差异无统计学意义(t=-0.274,P>0.05);③不同程度的HDCP患者之间SOD水平差异有统计学意义(F=16.868,P<0.05);不同程度的HDCP患者之间尿酸的水平差异有统计学意义(F=24.603,P<0.05).结论 HDCP患者脂蛋白(a)、尿酸水平升高,SOD水平降低.临床上可通过检测脂蛋白(a)、SOD和尿酸综合判断妊娠期高血压疾病患者病情的发展与预后.%Objective To explore the clinical significance of lipoprotein( a ), superoxide dismutase ( SOD ) and uric acid level in patients with hypertensive disorders complication pregnancy ( HDCP ). Methods Serum lipoprotein( a ), SOD and uric acid level of 67 cases ( including 21 cases in gestational hypertension group, 19 cases in mild preeclampsia group and 27 cases in severe preeclampsia group ) of HDCP were tested with automatic biochemistry analysator, and they were compared with those of 50 pregnant women with single birth and similar gestational weeks. Results The serum levels of lipoprotein( a ) and uric acid in HDCP group were higher than those of control group (t value was -4.879 and -7.410, respectively, bothP<0.05), and the serum level of SOD was lower than control group (t =5.658, P <0. 05 ). The serum levels of lipoprotein( a ) in gestational hypertension group, mild preeclampsia group and severe preeclampsia group increased gradually. There was significant difference in lipoprotein( a ) between severe preeclampsia group and mild preeclampsia group ( t = - 2. 109, P < 0.05 ), but there was no significant difference between gestational hypertension group and mild preeclampsia group( t = -0. 274,P >0. 05 ). The differences in the serum levels of SOD and uric acid among different groups with different degree of HDCP were statistically significant ( F = 16. 868 and 24. 603 , respectively, both P <0. 05 ). Conclusion The serum levels of lipoprotein( a ) and uric acid increase but the serum level of SOD decreases in patients with HDCP. Lipoprotein( a ), SOD and uric acid can be measured in clinics to synthetically judge the development and prognosis of HDCP.
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