首页> 外国专利> Gene therapeutic DNA vector based on VTvaf17 gene therapeutic DNA vector, carrying a target gene selected from the group of SOD1, SOD2, SOD3, CAT genes to increase the expression level of these target genes, method for its preparation and use, Escherichia coli strain SCS110-AF / VTvaf17- SOD1 or Escherichia coli SCS110-AF / VTvaf17-SOD2 or Escherichia coli SCS110-AF / VTvaf17-SOD3 or Escherichia coli SCS110-AF / VTvaf17-CAT, carrying a gene therapy DNA vector, a method for its production, a method for the industrial production of gene therapy DNA of vector

Gene therapeutic DNA vector based on VTvaf17 gene therapeutic DNA vector, carrying a target gene selected from the group of SOD1, SOD2, SOD3, CAT genes to increase the expression level of these target genes, method for its preparation and use, Escherichia coli strain SCS110-AF / VTvaf17- SOD1 or Escherichia coli SCS110-AF / VTvaf17-SOD2 or Escherichia coli SCS110-AF / VTvaf17-SOD3 or Escherichia coli SCS110-AF / VTvaf17-CAT, carrying a gene therapy DNA vector, a method for its production, a method for the industrial production of gene therapy DNA of vector

机译：基于VTvaf17基因治疗性DNA载体的基因治疗性DNA载体，其携带选自SOD1，SOD2，SOD3，CAT基因的靶基因以增加这些靶基因的表达水平，其制备和使用方法，大肠杆菌菌株SCS110 -AF / VTvaf17- SOD1或大肠杆菌SCS110-AF / VTvaf17-SOD2或大肠杆菌SCS110-AF / VTvaf17-SOD3或大肠杆菌SCS110-AF / VTvaf17-CAT，带有基因治疗DNA载体，是其生产方法，一种载体基因治疗DNA的工业化生产方法

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摘要

The invention refers to genetic engineering, can be used in biotechnology, medicine, agriculture for creating gene therapy drugs. A gene therapy DNA vector based on gene therapy DNA vector VTvaflV carrying a therapeutic gene selected from the group of SOD1, SOD2, SOD3, CAT genes to increase the expression level of the therapeutic gene in humans and animals. The gene therapy DNA vector VTvaflV- SOD1 or VTvafl7-SOD2 or VTvafl7-SOD3 or VTvafl7-CAT has a nucleotide sequence SEQ ID No. 1 or SEQ ID No. 2 or SEQ ID No. 3 or SEQ ID No. 4, respectively. The vector does not contain nucleotide sequences of viral origin, antibiotic resistance genes, providing its safe use for genetic therapy in humans and animals. A method of production of the vector, a method of use of the vector, a Escherichia coli strain carrying the vector, a method of industrial production of the vector are proposed.

机译：本发明是指基因工程，可用于生物技术，医学，农业中，用于创造基因治疗药物。基于携带治疗基因的基因治疗DNA载体VTvaflV的基因治疗DNA载体，所述治疗基因选自SOD1，SOD2，SOD3，CAT基因，以增加人和动物中治疗基因的表达水平。基因治疗DNA载体VTvaflV-SOD1或VTvaf17-SOD2或VTvaf17-SOD3或VTvaf17-CAT分别具有核苷酸序列SEQ ID No.1或SEQ ID No.2或SEQ ID No.3或SEQ ID No.4。该载体不含病毒来源的核苷酸序列，抗生素抗性基因，可安全用于人类和动物的基因治疗。提出了载体的生产方法，载体的使用方法，携带该载体的大肠杆菌菌株，载体的工业生产方法。

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公开/公告号RU2018143698A

专利类型
公开/公告日2020-06-10

原文格式PDF
申请/专利权人 СЕЛЛ ЭНД ДЖИН ТЕРАПИ ЛТД (GB);ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ «ПРОРЫВНЫЕ ИННОВАЦИОННЫЕ ТЕХНОЛОГИИ» (RU);
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申请/专利号RU20180143698
发明设计人 САВЕЛИЕВА НАТАЛИА (AT);
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申请日2018-12-10
分类号C12N15/12;C12N15/70;C12N1/21;A61K48;C12R1/19;
国家 RU
入库时间 2022-08-21 11:03:10

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