目的 探讨血清抑制素A在监测、诊断异位妊娠及腹腔镜保守性手术治疗疗效方面的价值.方法 采用酶联双位点免疫检测252例异位妊娠患者的外周血清抑制素A,其中持续性异位妊娠组23例、非持续性异位妊娠组229例;采用放射免疫法测定术前1天及术后人绒毛膜促性腺激素水平及其变化.结果 ①持续性异位妊娠组术前1天血清抑制素A水平明显高于非持续性异位妊娠组(t=5.651,P<0.01);②以术前1天血清抑制素A水平≥178ng/L为阈值,预测持续性异位妊娠发生的敏感度和特异度分别为84.56%和96.55%.结论 联合监测血清抑制素A及人绒毛膜促性腺激素可作为早期持续性异位妊娠的筛查试验.%Objective To evaluate clinical value of detection of serum inhibin-A level for monitoring and dianozing ectopie pregnancy (EP)and for predicting occurrence of PEP after conservative laparscopic salpingotomy. Methods ELISA was used to detect serum level of inhibin-A of 23 pregnant women with persistant ectopic pregnancy (PEP) ( PEP group) and 229 women without PEP ( Non-PEP group) at one day before the operation and post operation respectively. And radioimmunoassay (RIA) was used to detect serum level of β-hCG of all pregnant women at one day before the operation and post operation respectively. Results ① The serum inhibin-A level of women in PEP group at 1 day before operation was significantly higher than that in Non-PEP group ( t = 5.651, P ＜ 0. 01 ) ;②Using serum inhibin-A level ≥178 ng/L at one day before operation as threshold, the sensitivity and specificity for PEP prediction were 84.56％ and 96.55％respectively. Conclusion Jointly monitoring of serum levels of inhibin-A and β-hCG can be as a screening method of early PEP.
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