目的：研究膜叶槌果藤水提物镇痛抗炎作用。方法：小鼠分别连续灌胃给予膜叶槌果藤水提物高、中、低剂量（10.88，5.44，2.72 g/kg）7 d，采用扭体法、福尔马林致痛模型、二甲苯致耳肿胀模型及腹腔毛细血管通透性实验，观察其镇痛抗炎作用。结果：膜叶槌果藤水提物可显著抑制冰醋酸引起的小鼠扭体反应次数（P＜0.01）；对福尔马林致小鼠疼痛舔足第Ⅰ，Ⅱ时相累积时间均有显著减少（P＜0.05或P＜0.01）；对二甲苯致小鼠耳肿胀有显著的抑制作用（P＜0.05或P＜0.01）；对冰醋酸引起的毛细血管通透性也有显著的抑制作用（P＜0.01）。结论：膜叶槌果藤水提物具有显著的镇痛抗炎作用。%Objective:To study the analgesic and anti-inflammatory effects of capparis membranacea water extracts. Methods:Capparis membranacea aqueous extracts at high,middle and low doses(10.88,5.44,2.72 g/kg)were given respectively to mice by intragastric administration for 7 days. The analgesic and anti-inflammatory effects were observed through writhing response,formalin induced pain model,xylene induced ear swelling model and celiac capillary permeability test.Results:Capparis membranacea water extract can obviously inhibit the times of writhing response in mice induced by glacial acetic acid(P<0.01),the I,II phase accumulation time of mouse foot licking of formalin induced pain in mice reduced significantly(P<0.05 orP<0.01),xylene induced ear swelling in mice and capillary permeability induced by acetic acid were significantly inhibited(P<0.05 orP<0.01 andP<0.01).Conclusion:Capparis membranacea water extract has obvious analgesic and anti-inflammatory effects.
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