Objective To observe the analgesic and anti-inflammatory effects of the water extract of Glycosmis citrifolia (Willd.) Lindl.on mice and explore the mechanism. Methods The analgesic and anti-inflammatory effects were evaluated by 0.7% acetic acid-induced writhing test,the hot plate test,tests of dimethylbenzene-induced ear swelling,1% carrageenan-induced paw edema,determination of PGE2 in inflammatory feet,0.6% acetic acid-induced increase in peritoneal capillary permeability and cotton ball granuloma. Results The water extract of Glycosmis citrifolia (Willd.) Lindl.at low,medium and high doses can reduce the acetic acid-induced writhing times (P<0.01 or P<0.05),increase the pain threshold of mice (P<0.01 or P<0.05), inhibit dimethylbenzene-induced ear swelling (P<0.01 or P<0.05),1% carrageenan-induced paw edema (P<0.01 or P<0.05) and PGE2 production (P<0.01),0.6% acetic acid-induced increase of peritoneal capillary permeability (P<0.05),and the de-velopment of cotton ball granuloma (P<0.01 or P<0.05). Conclusion The water extract of Glycosmis citrifolia (Willd.) Lindl.shows analgesic and anti-inflammatory effects on mice.%目的：研究山桔叶水提物对小鼠的镇痛抗炎作用，并探讨其作用机制。方法采用0.7％醋酸致小鼠扭体反应、热板仪致小鼠疼痛、二甲苯致小鼠耳廓肿胀、1％角叉菜胶致小鼠足肿胀及测定炎足中前列腺素E2( PGE2)含量、0.6％醋酸致小鼠腹腔毛细血管通透性增加、小鼠棉球肉芽肿方法，观察山桔叶水提物镇痛抗炎作用。结果山桔叶水提物大、中、小剂量组醋酸致小鼠扭体反应次数减少(P<0.01或P<0.05)，提高热板致小鼠疼痛的痛阈值(P<0.01或P<0.05)；抑制二甲苯致小鼠耳廓肿胀度( P<0.01或P<0.05)、1％角叉菜胶致小鼠炎足肿胀( P<0.01或P<0.05)、1％角叉菜胶致小鼠炎足PGE2产生(P<0.01)、0.6％醋酸致小鼠腹腔通透性增加(P<0.05)及小鼠棉球肉芽肿产生(P<0.01或P<0.05)。结论山桔叶水提物对小鼠有镇痛抗炎作用。
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